ABSTRACT
OBJECTIVES: To describe the clinical and biological features of a series of immunophenotypic variant of B-CLL (v-CLL) characterised by intermediate RMH score, in the absence of t(11;14)(q13;q32) in FISH analysis in comparison with a series of typical CLL. METHODS: We studied the clinical and biological features of 63 cases of v-CLL and 130 cases of CLL. RESULTS: We observed significant differences in terms of age <70 yr (P < 0.001), lymphocytosis <20 x 10(9)/L (P < 0.001), lymphocyte doubling time Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/pathology
, Adult
, Aged
, Aged, 80 and over
, Female
, Gene Expression Profiling
, Gene Rearrangement
, Humans
, Immunoglobulin Heavy Chains
, Immunophenotyping
, In Situ Hybridization, Fluorescence
, Leukemia, Lymphocytic, Chronic, B-Cell/classification
, Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis
, Male
, Middle Aged
, Survival Analysis
, Young Adult
