[Cellular mechanisms of compensatory processes of the kidney in relation to the mass resected]. / Kletochnye mekhanizmy kompensatornykh protsessov v pochke v zavisimosti ot massy ee rezektsii.

As a result of comparative investigation of compensatory processes in the kidneys at various degree of their resection, the most general regularities in these processes have been revealed: an initial functional strain of renal cells and their ultrastructures, the secondary increase in hypertrophy and hyperplasia of the renal cells and their organelles. The degree of manifestation of these regular reactions directly depends on the mass of the resected part of the kidney. Subtotal resection of the kidney (80%) is an operation that gets out of the limits of the organ's compensatory possibilities. A sharp decrease, up to complete disappearance of its cellular division in 2-3 weeks after the operation is of great importance. Mechanism for development of renal insufficiency is evidently connected with absence of cellular renewal against the background of their hyperfunction and their quick worn out, that is, evidently, resulted in deficiency of renal epithelium and functional defectiveness connected with it in the remained renal mass.

[Clinico-morphologic analysis of compensatory and adaptive processes of the kidneys in chronic glomerulonephritis]. / Kliniko-morfologicheskii analiz kompensatorno-prisposobitel'nykh protsessov pochek pri khronicheskom glomerulonefrite.

Patients with different patterns of chronic glomerulonephritis (CGN) were distributed in 2 groups depending on the presence or lack of chronic renal failure (CRF). In renal biopsy specimens, the mitotic index was calculated and the comparison was made of the intensity of cell division with the degree of intracellular regeneration reactions and with the efficacy of the single-type multimodality pathogenetic therapy. None mitotic figure could be discovered in the renal tissue in all the cases of CGN complicated by CRF. In uncomplicated CGN, the patients were divided into 2 groups in terms of the intensity of cell division in the kidneys. One of the groups showed hyperplasia of the cells, whereas the other one manifested the low characteristics of the mitotic index. In the group of patients with a high level of cell division, the intracellular regeneration processes in the kidneys were more pronounced and the treatment appeared more effective. The level of cell division in renal biopsy specimens may serve as an objective diagnostic criterion for CGN and its complication by CRF.