ABSTRACT
The inhibitory activity exerted by some derivatives with an asymmetrical triazine structure on the multiplication of certain viruses [parainfluenza type 1 Sendai virus, vesicular stomatitis virus, (VSV) herpes simplex type 1 virus (HSV)] was determined: the role of coupling with ribose and that of substitution by halogens on the lateral chain was pointed out.
Subject(s)
Antiviral Agents/pharmacology , Herpesvirus 1, Human/drug effects , Parainfluenza Virus 1, Human/drug effects , Respirovirus/drug effects , Triazines/pharmacology , Vesicular stomatitis Indiana virus/drug effects , Animals , Cell Line , Chick Embryo , Humans , Molecular Structure , Triazines/chemistryABSTRACT
Copper complexes of hydrazones derived from symmetrical triazines inhibit the multiplication of three different types of viruses (Sendai, HSV and VSV) showing as well a scavenger activity on O2- radicals. The results emphasize the antiviral activity of these complexes which have at the same time a O2- radical scavenger activity.
Subject(s)
Antiviral Agents/pharmacology , Copper/pharmacology , Triazines/pharmacology , Cells, Cultured/microbiology , Fibroblasts/microbiology , Humans , Luminescent Measurements , Parainfluenza Virus 1, Human/drug effects , Simplexvirus/drug effects , Structure-Activity Relationship , Vesicular stomatitis Indiana virus/drug effectsABSTRACT
Sendai virus (SV) stimulates in vitro the chemiluminescent emission (CHL) of human polymorphonuclear leucocytes (LPMN). The kinetics of CHL produced by LPMN depends on the structure of stimulus, the intensity being dependent of the immunological status of the subject. CHL induced by Sendai virus is similar to that given by phorbol-myristate (PMA) as regards the induction of an early maximum. To obtain CHL significant emission, an optimum ratio between LPM concentration and Sendai virus dilution is required. The maximum effect is obtained in a large scale of dilution of Sendai virus ranging from 6,000 to 16,000 uHA.
Subject(s)
Lymphocyte Activation , Neutrophils/microbiology , Parainfluenza Virus 1, Human/immunology , Cells, Cultured/drug effects , Cells, Cultured/metabolism , Cells, Cultured/microbiology , Humans , Luminescent Measurements , Lymphocyte Activation/drug effects , Neutrophils/drug effects , Neutrophils/metabolism , Time Factors , Zymosan/pharmacologyABSTRACT
The O2- scavenging activity of some ligands of asymmetrical triazine seems to be enhanced when complexed with copper. S1 Cu complex in concentration of 10(-8) M inhibits the multiplication of type 1 (Sendai) parainfluenza virus cultivated on MCA fragments. The possible mechanism of inhibition is discussed.
Subject(s)
Antiviral Agents/pharmacology , Copper/pharmacology , Parainfluenza Virus 1, Human/drug effects , Superoxides/metabolism , Triazines/pharmacology , Virus Replication/drug effects , Parainfluenza Virus 1, Human/physiology , Structure-Activity RelationshipABSTRACT
According to their chemical structure, asymmetric triazine derivatives have an activator or scavenger action in a superoxide radical generating system. Complexation with Cu2+ of one of the derivatives enhanced its scavenger activity.
