ABSTRACT
Venous Ulcers (VU) represent 60-80% of all leg ulcers and are the final stage of the disease secondary to venous hypertension or valve insufficiency. Conventional treatment that focuses on its etiological factors continues to be the gold standard; however, 30% of ulcers do not heal with this treatment; thus, it has been seen that the use of growth factor can be used as an adjuvant for this pathology. A literature review was carried out to evaluate the evidence from systematic reviews, meta-analyses, case studies, and quantitative studies that respond to the objective of this analysis review in the different databases with specific inclusion criteria with publications between 2002 and 2022, initially finding the topical application of the factor and later, more recently, the intralesional and perilesional application, the latter being an alternative treatment for this type of pathology and generating some recommendations for using the Factor.
Subject(s)
Hypertension , Leg Ulcer , Varicose Ulcer , Humans , Varicose Ulcer/diagnosis , Varicose Ulcer/drug therapy , Databases, Factual , EGF Family of ProteinsABSTRACT
Thick film, the standard diagnostic procedure for malaria, is not always ordered promptly. A failsafe diagnostic strategy using an XE-2100 analyzer is proposed, and for this strategy, malaria diagnostic models for the XE-2100 were developed and tested for accuracy. Two hundred eighty-one samples were distributed into Plasmodium vivax, P. falciparum, and acute febrile syndrome groups for model construction. Model validation was performed using 60% of malaria cases and a composite control group of samples from AFS and healthy participants from endemic and non-endemic regions. For P. vivax, two observer-dependent models (accuracy = 95.3-96.9%), one non-observer-dependent model using built-in variables (accuracy = 94.7%), and one non-observer-dependent model using new and built-in variables (accuracy = 96.8%) were developed. For P. falciparum, two non-observer-dependent models (accuracies = 85% and 89%) were developed. These models could be used by health personnel or be integrated as a malaria alarm for the XE-2100 to prompt early malaria microscopic diagnosis.
Subject(s)
Hematologic Tests/instrumentation , Malaria, Falciparum/blood , Malaria, Falciparum/diagnosis , Malaria, Vivax/blood , Malaria, Vivax/diagnosis , Adult , Animals , Female , Hematologic Tests/methods , Humans , Leukocyte Count , Male , Models, Biological , Plasmodium falciparum , Plasmodium vivax , Predictive Value of Tests , Young AdultABSTRACT
De acuerdo con la literatura científica, la infección por Helicobacter pylori (H. pylori) es un problema creciente de salud pública en países en vía de desarrollo, como Colombia, con graves repercusiones gastrointestinales y extradigestivas, como son las alteraciones hematológicas, principalmente asociadas con las plaquetas, que pueden aumentar el riesgo cardiovascular, en particular el recuento de plaquetas y el porcentaje de plaquetas inmaduras. Objetivo: determinar la relación entre la infección por H. pylori y la presencia de alteraciones plaquetarias en una población sana de individuos...
