ABSTRACT
Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Circular RNA circ-SMAD7 promoted glioma cell proliferation and metastasis by upregulating PCNA, by C.-Y. Zuo, W. Qian, C.-J. Huang, J. Lu, published in Eur Rev Med Pharmacol Sci 2019; 23 (22): 10035-10041-DOI: 10.26355/eurrev_201911_19570 -PMID: 31799673" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/19570.
ABSTRACT
OBJECTIVE: Recent studies have discovered a class of circular RNAs (circRNAs), which are dysregulated in various tumors and participate in the regulation of tumor progression. In our research, we aim to research the function of circ-SMAD7 in the progression of glioma. PATIENTS AND METHODS: Circ-SMAD7 expression was detected by quantitative Real Time Polymerase Chain Reaction (qRT-PCR) in glioma tissue patients. Pearson's Chi-square test was used to determine the association of circ-SMAD7 expression with several clinicopathological factors. Besides, cell proliferation assay, cell cycle assay, transwell assay, and Matrigel assay were conducted to detect the function of circ-SMAD7 in glioma. In addition, the interaction between circ-SMAD7 and proliferating cell nuclear antigen (PCNA) in glioma was studied by performing qRT-PCR and Western blot assay. RESULTS: Circ-SMAD7 expression was observed in glioma tissues when compared with adjacent samples. The expression of circ-SMAD7 was associated with patients' WHO stage and KPS score. Cell proliferation was inhibited and cell cycle was regulated after circ-SMAD7 was downregulated in glioma cells. Besides, cell migration and invasion were inhibited after circ-SMAD7 was downregulated in glioma cells. In addition, the mRNA and protein expression of PCNA was repressed after circ-SMAD7 was knocked down in glioma cells. Furthermore, PCNA expression level positively correlated to circ-SMAD7 expression level in glioma samples. CONCLUSIONS: Our study suggests that circ-SMAD7 promotes proliferation and metastasis of glioma via upregulating PCNA. Circ-SMAD7/ PCNA might be a novel therapeutic strategy in glioma.
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Objective: To investigate the clinical characteristics and causes of misdiagnosis of esophageal bronchial fistula secondary to esophageal diverticulum. Methods: A case of esophageal bronchial fistula secondary to esophageal diverticulum was described with regard to its diagnosis and treatment process. A systematic literature review was performed for similar published cases in Wanfang, CNKI and Pubmed databases, using the key words "esophageal diverticulum, esophageal bronchial fistula" from January 1946 to August 2017. Results: The patient was a 52 year-old man with a history of persistent cough with yellow purulent sputum for more than 20 years, which aggravated with hemoptysis for more than a year. He had been hospitalized several times at the local hospitals, and had undergone chest X radiography and computed tomography(CT) several times. He was variably diagnosed with pulmonary infection, bronchiectasis accompanied by infection, and pulmonary abscess. One year ago, the symptoms aggravated with excessive yellow purulent sputum, increased hemoptysis and progressive chest CT lesions. At Peking Union Medical College Hospital, the patient underwent upper gastrointestinal contrast and electronic gastroscopy, and was diagnosed with middle and lower segment esophageal diverticulum complicated with esophageal-bronchial fistula. He was referred to the local thoracic surgery department for a curative procedure. By literature review, we found 15 relevant Chinese articles and 15 English articles. A total of 35 cases had been reported. In 28 misdiagnosed cases, lung infection was the most frequently diagnosed disease(19 cases), followed by bronchiectasis(6 cases) and pulmonary abscess(4 cases). All cases had a history of choking and coughing upon consuming liquids, and were confirmed through upper gastrointestinal contrast and/or electronic gastroscopy. Conclusion: Esophageal bronchial fistula with esophageal diverticulum is a rare condition that can be misdiagnosed as bronchiectasis or chronic pulmonary abscess, due to the similarities in their clinical manifestations and imaging features. Detailed history-taking and upper gastrointestinal contrast, gastroscopy and/or bronchoscopy are useful for a timely and correct diagnosis. The recommended treatment for esophageal fistula secondary to esophageal diverticulum is immediate surgery.
Subject(s)
Bronchial Fistula , Esophageal Fistula , Bronchiectasis , Bronchoscopy , Cough , Diagnostic Errors , Diverticulum, Esophageal , Hemoptysis , Humans , Lung Abscess , Male , Middle Aged , Radiography , Tomography, X-Ray ComputedABSTRACT
The dynamic features of nanosecond laser-induced cavitation bubbles near the light alloy boundary were investigated with the high-speed photography. The shock-waves and the dynamic characteristics of the cavitation bubbles generated by the laser were detected using the hydrophone. The dynamic features and strengthening mechanism of cavitation bubbles were studied. The strengthening mechanisms of cavitation bubble were discussed when the relative distance parameter γ was within the range of 0.5-2.5. It showed that the strengthening mechanisms caused by liquid jet or shock-waves depended on γ much. The research results provided a new strengthening method based on laser-induced cavitation shotless peening (CSP).
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Twenty-six patients were interviewed in five clinics at the Hunan Medical School in the People's Republic of China to assess the degree to which patients presenting with medical problems had primarily underlying psychological and social concerns. Patients in all five clinics (paediatrics, internal medicine, otolaryngology, urology and gynaecology) demonstrated a high degree of non-medical concerns. Fear of cancer was common. Many patients mentioned concerns about their children, sexual problems, or other family problems. Both patients and physicians seemed to be comfortable discussing the patients' personal problems and concerns. A medical presentation of psychosocial concerns was as common in China as it is in the United States.
Subject(s)
Cross-Cultural Comparison , Physician-Patient Relations , Psychophysiologic Disorders/psychology , Sick Role , Adolescent , Adult , Anxiety Disorders/psychology , China , Family Practice , Female , Humans , Male , Middle Aged , Somatoform Disorders/psychologyABSTRACT
The authors studied depressive symptoms among 251 Chinese medical inpatients through the use of the Beck Depression Inventory. Assessment of 100 healthy Chinese volunteers validated the use of American score norms for Chinese subjects. A total of 47.8% of the 251 medical inpatients (N = 120) met the Beck scale criterion for depression. Beck scale scores varied with the occupation of patients and the severity of medical illness but did not vary with sex, age, marital status, duration of hospitalization, or medical diagnosis.
Subject(s)
Depression/diagnosis , Disease/psychology , Ethnicity , Hospitalization , Adolescent , Adult , Age Factors , Aged , Child , China/ethnology , Depression/epidemiology , Female , Humans , Male , Middle Aged , Occupations , Personality InventorySubject(s)
Psychotic Disorders/diagnosis , Referral and Consultation , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Hospitals, General , Humans , Male , Middle Aged , Sex FactorsABSTRACT
Thirty surgical patients receiving surgery for congenital heart or rheumatic heart disease were compared with a match control group on a battery of neuropsychological tests. Subjects were examined prior to surgery, 4 weeks post- and again 6 months postsurgery. Preoperative surgical subjects showed a generalized impairment in functioning suggestive of brain dysfunction secondary to hypoxia. Improvement following surgery was attributed to practice effects.
