ABSTRACT
A new phenolic derivative (1) and a new dihydrophenanthrene (2) were isolated from the aerial part of Dendrobium hainanense rofe, along with 12 known compounds. The structures of the new compounds were elucidated by spectroscopic analysisï¼and the relative configuration of compound 1 was determined by J-based configuration analysis (JBCA) method. Bioassay result indicated that compound 1 exhibited weak antibacterial activity against Canidia albicans and Ralstonia solanaceanum.
Subject(s)
Dendrobium/chemistry , Phenanthrenes/chemistry , Phenols/pharmacology , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Cell Line, Tumor , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Humans , Molecular Structure , Phenols/chemistry , Plant Components, Aerial/chemistryABSTRACT
A phytochemical investigation of the alkaloid constituents from Trigonostemon filipes Y. T. Chang et S. L. Mo led to the isolation of two new indole alkaloids, trigonostemine G (1) and trigonostemone J (2), together with two known ones, trigonostemine A (3) and trigonostemine B (4). Their structures were determined by extensive spectroscopic methods. Compounds 1-4 exhibited moderate AChE inhibitory activity with inhibition ratio of 31.6, 31.7, 41.7, and 42.4%, respectively. In addition, compounds 1-2 showed weak cytotoxicity against K562 and BEL-7402 human cancer cell lines.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Cholinesterase Inhibitors/isolation & purification , Euphorbiaceae/chemistry , Indole Alkaloids/isolation & purification , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Cholinesterase Inhibitors/chemistry , Cholinesterase Inhibitors/pharmacology , Drug Screening Assays, Antitumor , Humans , Indole Alkaloids/chemistry , Indole Alkaloids/pharmacology , K562 Cells , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Stems/chemistryABSTRACT
Two new sesquiterpenoids, named 2α-hydroxyxylaranol B (1) and 4ß-hydroxyxylaranol B (2), together with a known diterpenoid 3,4-seco-sonderianol (3) were isolated from the fermentation of endophytic fungus J3 of Ceriops tagal. Their structures were elucidated based on spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY and HMBC). All compounds were evaluated for their cytotoxic activities by MTT method, and compound 3 exhibited cytotoxic activities against K562, SGC-7901, and BEL-7402 cell lines.
Subject(s)
Endophytes/isolation & purification , Fungi/isolation & purification , Plant Leaves , Rhizophoraceae , Sesquiterpenes/chemistry , Sesquiterpenes/isolation & purification , Cytotoxins/chemistry , Cytotoxins/isolation & purification , Humans , K562 CellsABSTRACT
Five new eudesmane-type sesquiterpenoids (1-5), along with six known ones (6-11), were isolated from Chinese agarwood induced by artificial holing originating from Aquilaria sinensis (Lour.) Gilg (Thymelaeaceae). The structures of the new sesquiterpenoids were established by spectroscopic methods including UV, IR, MS, 1D, and 2D NMR. Compounds 1, 3, 6 and 7 exhibited antibacterial activities against both Staphylococcus aureus and Ralstonia solanacearum, and compound 5 only showed an inhibitory activity towards S. aureus. Compounds 1, 6, 7 and 10 showed weak acetylcholinesterase inhibitory activity.
Subject(s)
Anti-Bacterial Agents/chemistry , Cholinesterase Inhibitors/chemistry , Sesquiterpenes, Eudesmane/chemistry , Thymelaeaceae/chemistry , Anti-Bacterial Agents/isolation & purification , Cholinesterase Inhibitors/isolation & purification , Molecular Structure , Ralstonia/drug effects , Sesquiterpenes, Eudesmane/isolation & purification , Staphylococcus aureus/drug effects , Wood/chemistryABSTRACT
Phytochemical study on dragon's blood of Dracaena cambodiana led to a new steroidal saponin, cambodianoside G(1), and six known ones (2-7). The structure of the new compound was elucidated on the basis of detailed spectroscopic analysis. Evaluation of antibacterial activities showed that compound 7 exhibited antibacterial activity against Staphylococcus aureus.
Subject(s)
Dracaena/chemistry , Plant Extracts/chemistry , Saponins/isolation & purification , Steroids/isolation & purification , Anti-Bacterial Agents , Molecular Structure , Saponins/chemistry , Saponins/pharmacology , Staphylococcus aureus/drug effects , Steroids/chemistry , Steroids/pharmacologyABSTRACT
Three new phenolic compounds (1-3) were isolated from the heartwood of Dalbergia odorifera T. Chen. (Leguminosae). Their structures were established based on spectroscopic methods including 1D and 2D NMR (HSQC, COSY, HMBC and ROESY). Compound 2 exhibited cytotoxicity against BEL-7402 tumor cell lines.
Subject(s)
Antineoplastic Agents, Phytogenic/isolation & purification , Benzofurans/isolation & purification , Chromones/isolation & purification , Dalbergia/chemistry , Drugs, Chinese Herbal/isolation & purification , Flavonoids/isolation & purification , Heterocyclic Compounds, 4 or More Rings/isolation & purification , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Benzofurans/chemistry , Benzofurans/pharmacology , Chromones/chemistry , Chromones/pharmacology , Drug Screening Assays, Antitumor , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/pharmacology , Flavonoids/chemistry , Flavonoids/pharmacology , Heterocyclic Compounds, 4 or More Rings/chemistry , Heterocyclic Compounds, 4 or More Rings/pharmacology , Humans , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Phenols/chemistryABSTRACT
A phytochemical investigation on the peels of Clausena lansium (Lour.) Skeels led to the isolation of two new monoterpenoid coumarins, named clauslactone V (1) and clauslactone W (2), together with three known analogues (3-5). Their structures were elucidated by spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). All the compounds were evaluated for hypoglycemic activity, and compounds 1-5 showed α-glucosidase inhibitory activity in vitro.
Subject(s)
Clausena/chemistry , Coumarins/pharmacology , Drugs, Chinese Herbal/pharmacology , Glycoside Hydrolase Inhibitors/pharmacology , Hypoglycemic Agents/pharmacology , Monoterpenes/pharmacology , Coumarins/chemistry , Coumarins/isolation & purification , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/isolation & purification , Fruit/chemistry , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/isolation & purification , Hypoglycemic Agents/chemistry , Hypoglycemic Agents/isolation & purification , Molecular Structure , Monoterpenes/chemistry , Monoterpenes/isolation & purification , Plants, Medicinal , alpha-Glucosidases/drug effectsABSTRACT
AIM: To investigate the chemical constituents in the stems of Trigonostemon heterophyllus. METHOD: The chemical constituents were isolated by column chromatography on silica gel, Rp-18, and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Three compounds were isolated and identified as a new diterpene, trigonoheterene B (1), together with two known compounds, trigonostemone (2) and trigonochinene B (3). CONCLUSION: Compound 1 is new. Compounds 2 and 3 showed antibacterial activities.
Subject(s)
Diterpenes/chemistry , Drugs, Chinese Herbal/chemistry , Euphorbiaceae/chemistry , Plant Stems/chemistry , Diterpenes/isolation & purification , Drugs, Chinese Herbal/isolation & purification , Molecular StructureABSTRACT
Phytochemical investigation on the stems of Trigonostemonheterophyllus led to the isolation of a new lariciresinol-based lignan glycoside, trigonoheteran (1), together with a known lignan glycoside, aviculin (2). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and NOESY).
Subject(s)
Euphorbiaceae/chemistry , Glycosides/isolation & purification , Lignans/isolation & purification , Furans , Glycosides/chemistry , Lignans/chemistry , Molecular StructureABSTRACT
Five new sesquiterpenes (1-5) along with ten known ones were isolated from the heartwood of Dalbergia odorifrea T. Chen. Their structures were determined by spectroscopic techniques including MS, UV, IR, 1D and 2D NMR. Bioassay results showed that compounds 1 and 9 had inhibitory effect on Candida albicans, and compound 9 exhibited inhibitory effects on Staphylococcus aureus by paper disk diffusion method.
Subject(s)
Candida albicans/drug effects , Dalbergia/chemistry , Molecular Structure , Plant Extracts/pharmacology , Sesquiterpenes/pharmacology , Staphylococcus aureus/drug effects , Magnetic Resonance Spectroscopy , Medicine, Chinese Traditional , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plants, Medicinal , Sesquiterpenes/chemistry , Sesquiterpenes/isolation & purification , Wood/chemistryABSTRACT
AIM: To study the chemical constituents from the fermentation of the endophytic fungus HP-1 of Chinese eaglewood. METHODS: The chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20, and their structures were elucidated on the basis of spectroscopic analysis. RESULTS: Four compounds were isolated and identified as 3α, 3ß, 10ß-trimethyl-decahydroazuleno[6, 7]furan-8, 9, 14-triol (1), 4-hydroxyphenylacetic acid (2), 4-hydroxyphenethyl alcohol (3), and 5-hydroxymethyl-2-furancarboxaldehyde (4). CONCLUSION: Compound 1 was a new compound. Compound 2 showed antibacterial activity against Staphylococcus aureus.
Subject(s)
Anti-Bacterial Agents/pharmacology , Endophytes/chemistry , Fungi/chemistry , Phenylacetates/pharmacology , Sesquiterpenes/isolation & purification , Thymelaeaceae/microbiology , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/isolation & purification , Phenylacetates/chemistry , Phenylacetates/isolation & purification , Sesquiterpenes/chemistry , Wood/microbiologyABSTRACT
Six new steroidal saponins, cambodianosides A-F (1-6), together with seven known ones, were isolated from the dragon's blood of Dracaena cambodiana. The structures of 1-6 were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. The cytotoxicities of all the isolated compounds were evaluated in vitro against three human cancer cell lines, and compounds 7, 8, and 11 showed significant inhibitory activities.
Subject(s)
Antineoplastic Agents/chemistry , Dracaena/chemistry , Isoflavones/chemistry , Phytosterols/chemistry , Plant Extracts/chemistry , Saponins/chemistry , Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Cell Line, Tumor , Cell Survival/drug effects , Humans , Isoflavones/isolation & purification , Isoflavones/pharmacology , Magnetic Resonance Spectroscopy , Medicine, Traditional , Molecular Structure , Phytosterols/isolation & purification , Phytosterols/pharmacology , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Saponins/isolation & purification , Saponins/pharmacologyABSTRACT
One new norsesquiterpene (1), and four new sesquiterpenes (2 - 5), along with four known ones, were isolated from the twigs of Aglaia odorata var. microphyllina C. DC. Monogr. Their structures were established based on spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. Compounds 1, 3, and 6 showed cytotoxic activity against SGC-7901 tumor cell.
Subject(s)
Aglaia/chemistry , Antineoplastic Agents, Phytogenic/therapeutic use , Phytotherapy , Plant Extracts/therapeutic use , Sesquiterpenes/therapeutic use , Stomach Neoplasms/drug therapy , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/pharmacology , Cell Line, Tumor , Humans , Molecular Structure , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plant Stems , Sesquiterpenes/chemistry , Sesquiterpenes/isolation & purification , Sesquiterpenes/pharmacologyABSTRACT
Five new 2-(2-phenylethyl)chromone derivatives, qinanones A-E (1-5), together with eight known 2-(2-phenylethyl)chromone derivatives (6-13), were isolated from the Et2O extract of high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis. The structures of the new 2-(2-phenylethyl)chromones were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. In the bioassay for acetylcholinesterase inhibitors, compounds 1-6, 10, and 12 exhibited weak inhibitory activities (inhibition percentage ranged from 10 % to 24 % at the concentration of 50 µg/mL). Compared with other agarwoods, "Qi-Nan" was different in containing 2-(2-phenylethyl)chromones with unsubstituted chromone rings.
Subject(s)
Acetylcholinesterase/metabolism , Cholinesterase Inhibitors/isolation & purification , Drugs, Chinese Herbal/chemistry , Flavonoids/isolation & purification , Thymelaeaceae/chemistry , Cholinesterase Inhibitors/chemistry , Cholinesterase Inhibitors/pharmacology , Drugs, Chinese Herbal/pharmacology , Flavonoids/chemistry , Flavonoids/pharmacology , Molecular Structure , QiABSTRACT
Two new acridone alkaloids, 3-methoxy-1,4,5-trihydroxy-10-methylacridone (1) and 2,3-dimethoxy-1,4,5-trihydroxy-10-methylacridone (2), were isolated from the ethanol extract of the branch of Atalantia buxifolia. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR. Compounds 1 and 2 exhibited significant antibacterial activity against Staphylococcus aureus and weak inhibitory effect on acetylcholinesterase.
Subject(s)
Acridines/isolation & purification , Acridines/pharmacology , Alkaloids/isolation & purification , Alkaloids/pharmacology , Anti-Bacterial Agents/isolation & purification , Anti-Bacterial Agents/pharmacology , Cholinesterase Inhibitors/isolation & purification , Cholinesterase Inhibitors/pharmacology , Drugs, Chinese Herbal/isolation & purification , Drugs, Chinese Herbal/pharmacology , Rutaceae/chemistry , Acetylcholinesterase , Acridines/chemistry , Acridones , Alkaloids/chemistry , Anti-Bacterial Agents/chemistry , Cholinesterase Inhibitors/chemistry , Drugs, Chinese Herbal/chemistry , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , Plant Roots/chemistry , Staphylococcus aureus/drug effectsABSTRACT
A new phenanthrenequinone, named denbinobin B (1), together with three known phenanthrenes was isolated from the whole plant of Dendrobium sinense T. Tang et F.T. Wang, an endemic and endangered orchid to Hainan Island. The new compound was elucidated using a combination of 1D, 2D NMR (COSY, HMQC, and HMBC) techniques, and HR-ESI-MS analyses. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with the diameter of the inhibition zone of 16.5 mm.
Subject(s)
Anti-Bacterial Agents/pharmacology , Dendrobium/chemistry , Phenanthrenes/isolation & purification , Phenanthrenes/pharmacology , Anthraquinones , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/isolation & purification , China , Nuclear Magnetic Resonance, Biomolecular , Phenanthrenes/chemistry , Staphylococcus aureus/drug effectsABSTRACT
OBJECTIVE: To study the constituents from the stems of Aquilaria sinensis. METHOD: The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral analysis including NMR and MS data. RESULT: Sixteen compounds were isolated and identified as threo-buddlenol C (1), thero-ficusesquilignan A (2), erythro-buddlenol C (3), (+/-) buddlenol D (4), (-) medioresinol (5), (-) pinoresinol (6), 5'-methoxy lariciresinol (7), erythro-guaiacylglycerol-beta-coniferyl ether (8), thero-guaiacylglycerol-beta-coniferyl ether (9), herpetin (10), (+) syringaresinol (11), curuilignan (12), ciwujiatone (13), coniferyl alcohol (14), 3, 4, 5-trimethoxyphenol (15) and cucurbitacin (16). CONCLUSION: All the compounds, except for 11-13 were obtained from A. sinensis for the first time.
Subject(s)
Drugs, Chinese Herbal/chemistry , Plant Stems/chemistry , Thymelaeaceae/chemistry , Drugs, Chinese Herbal/isolation & purification , Furans/chemistry , Furans/isolation & purification , Lignans/chemistry , Lignans/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Spectrometry, Mass, Electrospray IonizationABSTRACT
To investigate the chemical constituents of the endophytic fungus Penicillium sp. FJ-1 of Ceriops tagal, the chemical constituents were isolated by column chromatography on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic analysis. Their antibacterial activity was tested by paper disco diffusion method. Two compounds were isolated and identified as 7-hydroxy-deoxytalaroflavone (1), and deoxytalaroflavone (2). Compound 1 is a new compound, and compounds 1 and 2 showed weak activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
Subject(s)
Anti-Bacterial Agents/isolation & purification , Flavones/isolation & purification , Penicillium/chemistry , Rhizophoraceae/microbiology , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Flavones/chemistry , Flavones/pharmacology , Methicillin-Resistant Staphylococcus aureus/drug effects , Molecular Structure , Penicillium/isolation & purification , Staphylococcus aureus/drug effectsABSTRACT
Three new indole alkaloids, named kopsihainin D (1), kopsihainin E (2), and kopsihainin F (3), along with nine known compounds (4-12) were isolated from the twigs of Kopsia hainanensis. The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. Compounds 1 - 3 and 5 showed inhibitory activity against Staphylococcus aureus with an antibacterial circle diameter of 11.2, 9.1, 10.3 and 9.7 mm, respectively.
Subject(s)
Anti-Bacterial Agents/pharmacology , Apocynaceae/chemistry , Drugs, Chinese Herbal/chemistry , Drugs, Chinese Herbal/pharmacology , Indole Alkaloids/isolation & purification , Indole Alkaloids/pharmacology , Staphylococcus aureus/drug effects , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/isolation & purification , Drugs, Chinese Herbal/isolation & purification , Microbial Sensitivity Tests , Molecular Structure , Plant Stems/chemistryABSTRACT
Two new meroterpenes, guignardone D (1) and guignardone E (2), were isolated from endophytic fungus A1 of Scyphiphora hydrophyllacea Gaertn. F. Their structures were established based on spectroscopic methods including 1D and 2D NMR (HMQC, (1)H-(1)H COSY, HMBC, and ROESY).
