Chinese characters carry special anatomical connotations.

In the domain of anatomy, some Chinese characters in anatomical terms possess distinctive morphological significance. Chinese characters evolved from pictographic characters, with some of these pictographs being created by ancient people based on their own body structure. This implies that the comprehension and depiction of the human body structure have been integral since the inception of Chinese characters, and this knowledge has been passed down and developed through the continued inheritance of Chinese characters. Even today, certain characters retain the appearance to reflect the shape of the human body structure. By examining the characters related to vertebrae, cranial fontanel and heart, we can find the unique and enduring link between Chinese characters and the fields of anatomy as well as Chinese traditional medicine.

Using fractal dimension analysis to assess the effects of normal aging and sex on subregional cortex alterations across the lifespan from a Chinese dataset.

Fractal dimension (FD) is used to quantify brain structural complexity and is more sensitive to morphological variability than other cortical measures. However, the effects of normal aging and sex on FD are not fully understood. In this study, age- and sex-related differences in FD were investigated in a sample of 448 adults age of 19-80 years from a Chinese dataset. The FD was estimated with the surface-based morphometry (SBM) approach, sex differences were analyzed on a vertex level, and correlations between FD and age were examined. Generalized additive models (GAMs) were used to characterize the trajectories of age-related changes in 68 regions based on the Desikan-Killiany atlas. The SBM results showed sex differences in the entire sample and 3 subgroups defined by age. GAM results demonstrated that the FD values of 51 regions were significantly correlated with age. The trajectories of changes can be classified into 4 main patterns. Our results indicate that sex differences in FD are evident across developmental stages. Age-related trajectories in FD are not homogeneous across the cerebral cortex. Our results extend previous findings and provide a foundation for future investigation of the underlying mechanism.

Relationship between local gyrification index and age, intelligence quotient, symptom severity with Autism Spectrum Disorder: A large-scale MRI study.

Gyrification is one of the most important characteristics in the cerebral cortex and the local gyrification index (LGI) was used to quantify the regional changes in gyrification. The aim of this study was to evaluate LGI alterations in autism spectrum disorder (ASD) individuals in comparison with typically developing (TD) controls and the association of the LGI with age, intelligence quotient (IQ), and symptom severity in a large multicenter dataset. Structural MRI datasets selected from Autism Brain Imaging Data Exchange I and II (ABIDE I and ABIDE II) repository (606 ASD individuals and 765 age-matched TD controls) were used to calculate LGI values. The correlation between the LGI and age, IQ, and other clinical measurements were assessed. No differences in LGI were found between ASD individuals and TD controls after FDR multiple comparison correction, however, LGI decreased with age in both ASD and TD groups. In the TD group, a significant positive correlation was found between the LGI and full IQ (FIQ) in the parahippocampal gyrus, parsopercularis of left hemisphere and entorhinal cortex, parahippocampal, superior temporal gyrus of right hemisphere, but was not observed in the ASD group. Furthermore, a positive correlation between the LGI and Autism Diagnostic Interview-Revised (ADI-R) Repetitive and Restrictive Behaviors (RRB) score was found in the left inferior parietal lobule, lateral occipital cortex, superior frontal gyrus and right superior frontal gyrus, inferior temporal gyrus. In summary, these results demonstrate that the ASD is a truly heterogeneous neurodevelopmental disorder. Future investigations are required that group ASD patients into more homogeneous subtypes.

A Hands-On Organ-Slicing Activity to Teach the Cross-Sectional Anatomy.

The presentation of pre-sliced specimens is a frequently used method in the laboratory teaching of cross-sectional anatomy. In the present study, a new teaching method based on a hands-on slicing activity was introduced into the teaching of brain, heart, and liver cross-sectional anatomy. A randomized, controlled trial was performed. A total of 182 third-year medical students were randomized into a control group taught with the prosection mode (pre-sliced organ viewing) and an experimental group taught with the dissection mode (hands-on organ slicing). These teaching methods were assessed by testing the students' knowledge of cross-sectional specimens and cross-sectional radiological images, and analyzing students' feedback. Using a specimen test on three organs (brain, heart, and liver), significant differences were observed in the mean scores of the control and experimental groups: for brain 59.6% (±14.2) vs. 70.1% (±15.5), (P < 0.001, Cohen's d = 0.17); for heart: 57.6% (±12.5) vs. 75.6% (±15.3), (P < 0.001, d = 0.30); and for liver: 60.4% (±14.5) vs. 81.7% (±14.2), (P < 0.001, d = 0.46). In a cross-sectional radiological image test, better performance was also found in the experimental group (P < 0.001). The mean scores of the control vs. experimental groups were as follows: for brain imaging 63.9% (±15.1) vs. 71.1% (±16.1); for heart imaging 64.7% (±14.5) vs. 75.2% (±15.5); and for liver imaging 61.1% (±15.5) vs. 81.2% (±14.6), respectively. The effect sizes (Cohen's d) were 0.05, 0.23, and 0.52, respectively. Students in the lower tertile benefited the most from the slicing experiences. Students' feedback was generally positive. Hands-on slicing activity can increase the effectiveness of anatomy teaching and increase students' ability to interpret radiological images.

Kohn's pores are not responsible for collateral ventilation between inflated and deflated segments: a microscopic study of pulmonary intersegmental septa in the human lung.

The composition of the pulmonary intersegmental septum has not been clearly identified by thoracic surgeons who regard Kohn's pores as the main channel that causes air leakage when determining the intersegmental septum by segmental ventilation. In this study, we aimed to examine this possible misinterpretation by focusing on a detailed description of the microscopic anatomy of the intersegmental septum. To accomplish this aim, 50 lung samples of the intersegmental septum from fresh cadavers without emphysema were studied by histological and electron microscopy. The findings of light microscopy and electron microscopy showed that the intersegmental septum is composed of three layers. The alveolar walls of adjacent segments serve as the superficial layer. They are integral, and no Kohn's pores were identified. The deep layer contains collagen fibres. As shown by our findings, Kohn's pores are absent within the intersegmental septum. Therefore, they could not be the main channel for the collateral ventilation between inflated and deflated lung segments during a pulmonary segmentectomy.

Preconditioning crush increases the survival rate of motor neurons after spinal root avulsion.

In a previous study, heat shock protein 27 was persistently upregulated in ventral motor neurons following nerve root avulsion or crush. Here, we examined whether the upregulation of heat shock protein 27 would increase the survival rate of motor neurons. Rats were divided into two groups: an avulsion-only group (avulsion of the L4 lumbar nerve root only) and a crush-avulsion group (the L4 lumbar nerve root was crushed 1 week prior to the avulsion). Immunofluorescent staining revealed that the survival rate of motor neurons was significantly greater in the crush-avulsion group than in the avulsion-only group, and this difference remained for at least 5 weeks after avulsion. The higher neuronal survival rate may be explained by the upregulation of heat shock protein 27 expression in motor neurons in the crush-avulsion group. Furthermore, preconditioning crush greatly attenuated the expression of nitric oxide synthase in the motor neurons. Our findings indicate that the neuroprotective action of preconditioning crush is mediated through the upregulation of heat shock protein 27 expression and the attenuation of neuronal nitric oxide synthase upregulation following avulsion.

Pulmonary intersegmental planes: imaging appearance and possible reasons leading to their visualization.

PURPOSE: To describe the normal imaging appearance of pulmonary intersegmental planes on thoracic computed tomographic (CT) scans and determine the possible reasons related to their visualization in terms of aging and anatomy. MATERIALS AND METHODS: The study was approved by the internal ethics review board. Informed consent was obtained. A retrospective review was undertaken of 104 thoracic multidetector CT scans of an older group (>65 years) and younger group (<55 years). The number, location, and appearance rate of intersegmental planes were assessed. Group comparisons were made, and linear regression analysis was used to assess relationships between age and visualization of intersegmental planes. Thirty lung samples (10 × 10 × 10 mm(3)) from autopsy were scanned by using micro-CT. Thicknesses of intersegmental planes were measured. Significant differences of the thickness between visible and invisible intersegmental planes were assessed with the independent t test. In five fetal specimens (17-21 weeks in gestational age), 7.0-T magnetic resonance (MR) imaging was performed to determine the congenital difference of thickness of intersegmental planes. RESULTS: Within the right lung, appearance rates of visible intersegmental planes were 71.2% at S1-S3, 54.8% at S4-S5, and 70.2% at S7-S10. Within the left lung, appearance rates of visible intersegmental planes were 39.4% at S1+2 to S3, 64.4% at S4-S5, 18.3% at S7-S8, and 89.4% at S7-S10. Appearance rates of visible intersegmental planes on thoracic CT scans were not significantly different (P ≥ .38) between younger and older groups. Mean thicknesses of visible and invisible intersegmental planes were 681.3 µm ± 75.3 (standard deviation) and 221.7 µm ± 54.1, respectively. Visible intersegmental planes were significantly thicker than invisible intersegmental planes (P < .05). Visible intersegmental planes were also seen on fetal lung 7.0-T MR images. CONCLUSION: The thickness of pulmonary intersegmental planes and variation of intersegmental veins were closely related to visualization of intersegmental planes on thoracic CT scans. Aging was excluded as the possible reason.