[Stimulation of Brucella clearance in rats after treatment with BCG suspensions]. / Steigerung der Brucella-Clearance bei der Ratte nach Behandlung mit BCG-Suspensionen.

Intraperitoneal application of BCG induced a significantly increased clearance of Brucella in rats. The effect starts three days after application of 7 mg BCG to the rat and continued for eight weeks. This effect could be used for estimation of efficiency of BCG for nonspecific resistance stimulation. Comparative investigation of seven different batches reveals that three BCG preparations induce an unspecific resistance more than eight weeks, one for two weeks and three batches exerted no effect. Addition of Gelafusal as a stabilizer prolonged durability for about two weeks.

[BCG-vaccination in GDR (author's transl)]. / Die BCG-Impfung in der DDR.

Report on the development of BCG-vaccination in GDR, appreciating the initiative and the contribution of Prof. Hans Knöll. BCG-vaccination has a great portion of the steady reduction of tuberculosis morbidity among children and young adults and the practical disappearance of mortality in these age groups.

[Search for nucleic acid influencing, as well as membrane active, potential cancerostatic fungal metabolites using microbiological and cytological screening methods]. / Suche nach Nucleinsäurestoffwechsel-beeinflussenden sowie membranaktiven potentiell cancerostatisch wirksamen Pilzinhaltsstoffen durch mikrobiologische und cytologische Screeningmethoden.

A prescreening program including microbiological and cytological assays was employed in search of potential cancerostatic antibiotics in crude extracts of mushrooms. The microbiological tests based on agar diffusion techniques consist of prophage induction test and BIP-test. All active compounds selected by these microbiological models are potential inhibitors of nucleic acid metabolism. Cytological assays on leukemia L 1210 cells have been carried out by microscopic examination and by evaluation using an electronic particle counter. Activity was expressed as decrease of the number of single cells caused by agglutination or lysis of cells, changes in cell surface area, dye exclusion, and increase of cell volume. A wide variety of mushrooms was demonstrated to exhibit interesting activities in some of these screening systems. The influence of primary metabolic products of mushrooms on microbiological models was studied additionally. In vivo assays have not yet been accomplished.