Subject(s)
Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Melanoma/pathology , Retrospective StudiesABSTRACT
We report a case of phyllodes tumor in a male patient following prolonged oestrogen therapy. The male mammary gland can be modified by oestrogen with a histological picture analogous to that of the female breast.
Subject(s)
Breast Neoplasms/complications , Diethylstilbestrol/adverse effects , Gynecomastia/complications , Neoplasms, Multiple Primary , Phyllodes Tumor/complications , Prostatic Neoplasms/drug therapy , Aged , Gynecomastia/chemically induced , Humans , Male , Neoplasms, Multiple Primary/pathology , Phyllodes Tumor/pathologyABSTRACT
Of a total of 83 patients with metastatic bone disease, surgery was performed in 17 cases at the prefracture stage, in 54 cases after complete fracture and in 10 cases to decompress the spinal cord. Positive short-term results were obtained in 75% of cases. 7 patients presented mild complications. In 2 cases, the patients had to be reoperated. 55% of the patients were still alive after 6 months, 31% after 12 months and 10% after 2 years.
Subject(s)
Bone Neoplasms/secondary , Bone and Bones/surgery , Palliative Care/methods , Adult , Aged , Aged, 80 and over , Bone Neoplasms/mortality , Bone Neoplasms/surgery , Female , Humans , Male , Middle Aged , Postoperative Complications/etiology , Prognosis , Quality of Life , ReoperationABSTRACT
We report a case of classical Kaposi's sarcoma (KS) in a patient affected by B-cell chronic lymphocytic leukemia for 2 years and who had not received any antiblastic treatment. At the ultrastructural analysis the leukemic cell showed rather immature features, and the immunologic phenotype (absence of detectable cytoplasmic Ig, and expression only of the DR, B2 and IgD lambda molecules on the surface membrane) proved its intermediate level of maturity, its monoclonality and relative rarity. The patient presented a complex immunologic deficiency, revealed not only by the monoclonality of the B lymphocytes and their low degree of maturity, but also by the almost total absence of T helper lymphocytes, by the high reduction in NK activity, by the very scarce proliferative response to the polyclonal mitogens PHA, ConA and PWM, and by a complete anergy to the skin test of delayed reactivity. The search for antibodies against the viruses EBV, CMV, HTLV-I and HTLV-III in the serum was negative. At the HLA typing, the patient was DR5, as are most classical KS and/or B-CLL patients. The data are discussed in relation to documented non-casual association between B-CLL and KS. We stress that immunosuppression may play an important role in the pathogenesis of both diseases and the possibility of their being conditioned by common genetic HLA-associated factors of predisposition.
