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Phytother Res ; 17(10): 1140-4, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14669245

ABSTRACT

The ethanol extract (95%) of the root of the plant Cryptolepis buchanani (EECB) was investigated for immunomodulatory activity in mice and rats. The oral administration of EECB caused significant stimulation of the delayed type hypersensitivity (DTH) reaction and humoral antibody production. The oral LD50 was found to be more than 3 g/kg in both rats and mice.


Subject(s)
Adjuvants, Immunologic/pharmacology , Cryptolepis , Phytotherapy , Plant Extracts/pharmacology , Adjuvants, Immunologic/administration & dosage , Adjuvants, Immunologic/therapeutic use , Administration, Oral , Animals , Antibody Formation/drug effects , Arthritis, Infectious/prevention & control , Dose-Response Relationship, Drug , Hypersensitivity, Delayed/prevention & control , Lethal Dose 50 , Male , Mice , Phagocytosis/drug effects , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant Roots , Rats
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