ABSTRACT
BACKGROUND: The effect of neoadjuvant chemotherapy on immediate microvascular breast reconstruction is of concern because any complication might delay adjuvant treatment. We sought to determine whether the complication rate is increased and whether the interval between surgery and subsequent treatment is delayed compared with patients without neoadjuvant chemotherapy. METHODS: Complication rates and interval from surgery until adjuvant treatment of patients with mastectomy for locally advanced breast cancer followed by immediate microvascular breast reconstruction (deep inferior epigastric perforator (DIEP) flap, transverse rectus abdominis musculocutaneous (TRAM) flap, superior gluteal artery perforator (SGAP) flap, transverse musculocutaneous gracilis (TMG) flap, or superficial inferior epigastric artery (SIEA) flap) after neoadjuvant chemotherapy were compared with those of patients who underwent immediate breast reconstruction without neoadjuvant chemotherapy. RESULTS: Forty-seven patients with locally advanced breast cancers who underwent neoadjuvant chemotherapy before mastectomy and immediate microvascular reconstruction and 52 patients without neoadjuvant chemotherapy were identified. 36% of patients with neoadjuvant chemotherapy had one or more complications compared with 29% of patients without previous chemotherapy, but this difference was not statistically significant. The occurrence of complications in patients with neoadjuvant chemotherapy did not result in a delayed start of adjuvant treatment compared with patients without complications after neoadjuvant chemotherapy (43.6 vs. 44.6 days). CONCLUSIONS: Immediate microvascular breast reconstruction after neoadjuvant chemotherapy does not result in an increased complication rate or delay the start of adjuvant treatment even if complications occur and therefore can be performed safely in patients with locally advanced breast cancer.
Subject(s)
Antineoplastic Agents/administration & dosage , Breast Neoplasms/drug therapy , Breast Neoplasms/surgery , Mammaplasty/methods , Surgical Flaps , Adult , Aged , Antineoplastic Agents/adverse effects , Breast/surgery , Breast Neoplasms/pathology , Female , Humans , Mastectomy , Middle Aged , Neoadjuvant Therapy , Surgical Flaps/blood supply , Time FactorsABSTRACT
The efficacy of free fasciocutaneous flaps for the treatment of chronic osteomyelitis of the tibia was evaluated in a retrospective study. A series of 14 patients is reported who underwent soft-tissue reconstruction using different free fasciocutaneous flaps after radical debridement. Radical debridement and microvascular reconstruction were performed in two operative steps. The mean duration of disease was 14 years (range: 6 months to 37 years). At a mean follow-up of 31.4 (12 to 52) months, there was no evidence of recurrence of osteomyelitis. This retrospective study validates that fasciocutaneous flaps can be used for microsurgical soft-tissue reconstruction after radical debridement in the treatment of chronic osteomyelitis. The introduction of free fasciocutaneous flaps has challenged the dictum of the therapy of chronic osteomyelitis with muscle flaps.
