Adjuvant psychotherapy in early-stage bipolar disorder: study protocol for a randomized controlled trial.

BACKGROUND: Bipolar disorders are serious illnesses with a chronic course and a high rate of relapse. Typically, bipolar disorders onset during adolescence or early adulthood, with patients experiencing significant personal and social costs as a consequence of their illness. Despite this, to date, there is limited (controlled) evidence regarding the effectiveness of psychotherapy during the critical stages of the disorder (e.g., early onset). Some preliminary studies suggest that targeted, tailored early interventions in particular may improve disease prognosis. The proposed study examines the effectiveness of group psychotherapy on relapse prevention, global adaptive functioning, and neuropsychological functioning in early-stage bipolar disorder. METHODS: In this multicenter randomized controlled trial (RCT), 300 patients with bipolar disorder are randomized to one of two group psychotherapies: Specific Emotional-Cognitive Therapy (SECT; intervention group) or Emotion-Focused Supportive Therapy (EFST; active control group). Each therapy comprises of a total of 48-h sessions (delivered once a month) over a period of 4 months. Assessments take place at baseline (t1); 6 months follow-up, i.e., post-intervention (t2); 12 months follow-up (t3); and 18 months follow-up (t4), whereby 18 months follow-up is the primary time point of interest. DISCUSSION: The goal of this study is to test the effects of an innovative, specific group therapy relative to an active control condition in terms of rates of relapse, global functioning, and neuropsychological functioning. Pending the outcomes of the trial, it will be possible to establish a firm evidence base for accessible group psychotherapy adjuvant to routine psychiatric care for individuals with bipolar disorder. TRIAL REGISTRATION: USA: ClinicalTrials.gov NCT02506322 . Registered on 19 December 2014; Germany: German Clinical Trials Register DRKS00006013 . Registered on21 May 2015.

Facial emotion recognition, theory of mind and the role of facial mimicry in depression.

BACKGROUND: This study examined whether acutely (aMDD) and remitted depressed patients (rMDD) show deficits in the two aspects of social cognition - facial emotion recognition (FER) and reasoning - when using ecologically valid material. Furthermore, we examined whether reduced facial mimicry mediates the association between depressive symptoms and FER, and whether FER deficits and reasoning deficits are associated. METHOD: In 42 aMDD, 43 rMDD, and 39 healthy controls (HC) FER was assessed using stimuli from the Amsterdam Dynamic Facial Expression Set, reasoning by the Movie for the Assessment of Social Cognition. Furthermore, the activity of Zygomaticus Major and Corrugator supercilii were recorded. RESULTS: aMDD recognized happy faces less accurately, were less confident recognizing happiness and anger and found it more difficult to recognize happiness, anger and fear than HC. rMDD were less confident recognizing anger and found it more difficult to recognize happiness, anger and fear than HC. Reduced mimicry did not explain FER deficits. aMDD but not rMDD showed impaired reasoning. LIMITATIONS: The stimulus material was comparably easy to decode. Therefore, it is possible that the FER deficits of aMDD and rMDD patients are more pronounced than demonstrated in this study. CONCLUSIONS: aMDD show deficits in FER and reasoning, whereas rMDD only show mild impairments in the recognition of emotional expressions. There must be other processes - besides mimicry - that serve the accurate recognition of emotional facial expressions.

Cognitive emotion regulation in euthymic bipolar disorder.

BACKGROUND: Based on findings indicating increased stress reactivity and prolonged stress recovery in individuals with bipolar disorder (BD), it has been proposed that emotion regulation (ER) deficits lie at the core of this disorder. Recent studies show an increased use of maladaptive ER strategies and a decreased use of adaptive ER strategies in BD. Whether this pattern is merely a correlate of affective episodes or might be a stable characteristic of BD, however, remains to be explored. In addition, it is unclear whether these deficits in ER are specific to people with a history of BD. METHODS: We examined whether euthymic BD individuals differ from healthy controls (HC) and individuals with a history of Major Depressive Disorder (MDD) with respect to the cognitive ER strategies they habitually use (CERQ) in response to negative affect. The sample consisted of 42 bipolar patients, 43 patients with MDD and 39 HC. RESULTS: Compared to HC, euthymic BD and MDD individuals reported increased use of rumination, catastrophizing, and self-blame alongside decreased use of positive reappraisal, and putting into perspective. No differences were found between BD and MDD groups. LIMITATIONS: These findings are based on self-reports reflecting the habitual use of ER-strategies. The use of more objective methods and the examination of the spontaneous use of ER-strategies in euthymic BD would be desirable. CONCLUSIONS: Deficits in the habitual use of ER strategies may characterize BD and MDD individuals even outside of an acute episode and thereby play a role in the recurrence of affective disorders.