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1.
Bull Exp Biol Med ; 171(2): 212-217, 2021 May.
Article in English | MEDLINE | ID: mdl-34173095

ABSTRACT

Using rat and mouse models of neurogenic, ethanol-induced, and indometacin-induced damage to the gastric mucosa we demonstrated that course preventive treatment with flavonoid complex from aerial parts of Lychnis chalcedonica L. increased the resistance of gastric mucosa to ulcerogenic factors of different etiology. The gastroprotective effect of the phytocomplex in a dose range of 16-1600 µg/kg was comparable with that of the reference drug plantaglucide and was superior to that of the reference drugs eleutherococcus extract and methyluracil in the therapeutic doses. The antiulcerogenic activity of Lychnis chalcedonica flavonoid complex considerably exceeded activity of Lychnis chalcedonica L. extract demonstrated in our previous experiments.


Subject(s)
Anti-Ulcer Agents/therapeutic use , Plant Extracts/therapeutic use , Stomach Ulcer/drug therapy , Animals , Animals, Outbred Strains , Anti-Ulcer Agents/isolation & purification , Anti-Ulcer Agents/pharmacology , Cytoprotection/drug effects , Disease Models, Animal , Ethanol , Flavonoids/isolation & purification , Flavonoids/pharmacology , Flavonoids/therapeutic use , Gastric Mucosa/drug effects , Gastric Mucosa/pathology , Indomethacin , Lychnis/chemistry , Male , Mice , Neurogenic Inflammation/drug therapy , Neurogenic Inflammation/pathology , Phytotherapy , Plant Extracts/pharmacology , Rats , Rats, Wistar , Silene , Stomach Ulcer/chemically induced , Stomach Ulcer/pathology
2.
Bull Exp Biol Med ; 153(1): 129-33, 2012 May.
Article in English | MEDLINE | ID: mdl-22808511

ABSTRACT

High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.


Subject(s)
Enzymes, Immobilized/therapeutic use , Granulocyte Colony-Stimulating Factor/therapeutic use , Hepatitis, Chronic/drug therapy , Hyaluronoglucosaminidase/therapeutic use , Animals , Male , Mice , Nanotechnology , Rats , Rats, Wistar , Regenerative Medicine
3.
Bull Exp Biol Med ; 150(3): 343-7, 2011 Jan.
Article in English | MEDLINE | ID: mdl-21240350

ABSTRACT

The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early terms after cytostatic treatment and more active maturation of neutrophils in the bone marrow due to enhanced secretion of humoral factors by elements of hemopoietic environment at late terms of the experiment.


Subject(s)
Cytostatic Agents/pharmacology , Granulocytes/drug effects , Hematopoiesis/drug effects , Imidazoles/pharmacology , Protective Agents/pharmacology , Animals , Caproates , Cyclophosphamide/pharmacology , Male , Mice , Mice, Inbred CBA , Statistics, Nonparametric
4.
Bull Exp Biol Med ; 151(1): 74-8, 2011 May.
Article in English | MEDLINE | ID: mdl-22442807

ABSTRACT

Immobilized hyaluronidase (nanotechnology method of electron-beam synthesis) exhibited high hepatoprotective activity on the model of Cl4-induced hepatitis. This agent produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects were shown to accompany stimulation of multipotent bone marrow precursors, mobilization of these cells into the peripheral blood, and cell migration to the target organ increasing the number of parenchymal progenitor cells in the liver. The mechanisms for targeted migration of progenitor cells suggest a decrease in SDF-1 production by bone marrow stromal cells and increase in the synthesis of this factor by microenvironmental cells of the liver tissue.


Subject(s)
Cytoprotection , Enzymes, Immobilized/therapeutic use , Hepatitis, Animal/drug therapy , Hyaluronoglucosaminidase/therapeutic use , Liver/drug effects , Multipotent Stem Cells/drug effects , Animals , Biomarkers/metabolism , Bone Marrow Cells/cytology , Bone Marrow Cells/drug effects , Carbon Tetrachloride , Cell Movement/drug effects , Cellular Microenvironment/drug effects , Chemokine CXCL12/metabolism , Enzymes, Immobilized/administration & dosage , Enzymes, Immobilized/chemistry , Hepatitis, Animal/metabolism , Hepatitis, Animal/pathology , Hyaluronoglucosaminidase/administration & dosage , Hyaluronoglucosaminidase/chemistry , Liver/metabolism , Liver/pathology , Mice , Multipotent Stem Cells/cytology , Nanotechnology , Rats , Stromal Cells/cytology , Stromal Cells/drug effects
5.
Bull Exp Biol Med ; 139(1): 27-31, 2005 Jan.
Article in English | MEDLINE | ID: mdl-16142268

ABSTRACT

We studied changes in the erythroid hemopoietic stem during blood loss of different severity. Stimulation of erythropoiesis during the posthemorrhagic period was related to functional activation of erythroid precursors, which resulted from changes in feeder capacity of cells from the hemopoiesis-inducing microenvironment and erythropoietic activity of the plasma. The development of encephalopathy under conditions of massive blood loss was accompanied by a reduction of erythroid hyperplasia due to a decrease in the number of proliferating erythroid precursor cells, despite high secretory activity of adherent myelokaryocytes, rise in erythropoietic activity of the plasma, increased formation of erythroid hemopoietic islets, and accelerated maturation of hemopoietic cells.


Subject(s)
Erythroid Precursor Cells/physiology , Erythropoiesis/physiology , Hemorrhage/physiopathology , Animals , Mice
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