Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Ann Thorac Surg ; 76(2): 487-92, 2003 Aug.
Article in English | MEDLINE | ID: mdl-12902091

ABSTRACT

BACKGROUND: We have retrospectively studied 254 patients who underwent a bivalvular mechanical mitral-aortic replacement in the cardiovascular and thoracic surgery unit of Nantes from 1979 to 1989. The follow-up was 22 years (1979 to 2001). The last patient was operated on 12 years before the end of the follow-up. METHODS: All mitral prostheses were St. Jude Medical (SJM) bileaflet valves, and the aortic prostheses were 124 monodisc Björk-Shiley valves, 3 Sorin prostheses, and 127 St. Jude Medical bileaflet prostheses. The mean age was 56.8 +/- 8.5 years with a sex ratio equal to 1. Rheumatism as the etiology predominated with 79.5%. Ninety-seven percent of the patients were followed for a total of 2,779 patient-years and a mean of 11.7 years. RESULTS: Operative mortality was 7.08%. Freedom from overall mortality and valve-related mortality at 22 years were 45.7% +/- 3.6% and 73.1% +/- 3%, respectively. The linearized rates of thromboembolic and hemorrhagic events were 1.07% and 0.9% per patient-year, respectively. Multivariate analysis showed age (p < 0.002), sex (p < 0.01), and degenerative etiology (p = 0.04) as independent factors of late mortality, and age, sex, degenerative disease, and tricuspid pathology were related to valve-related mortality. CONCLUSIONS: This study shows good results after mechanical mitral-aortic replacement in terms of survival rate and quality of life in surviving patients, and outlines the factors influencing long-term results as compared with isolated mitral valve replacement.


Subject(s)
Aortic Valve/surgery , Heart Valve Diseases/surgery , Heart Valve Prosthesis , Mitral Valve/surgery , Postoperative Complications/epidemiology , Actuarial Analysis , Adolescent , Adult , Age Distribution , Aged , Aortic Valve/physiopathology , Bioprosthesis , Child , Cohort Studies , Female , Follow-Up Studies , France/epidemiology , Heart Valve Diseases/mortality , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis Implantation/mortality , Humans , Incidence , Male , Middle Aged , Mitral Valve/physiopathology , Multivariate Analysis , Probability , Retrospective Studies , Risk Assessment , Sex Distribution , Time Factors , Treatment Outcome
2.
Prog Transplant ; 12(3): 176-80, 2002 Sep.
Article in English | MEDLINE | ID: mdl-12371042

ABSTRACT

OBJECTIVE: To compare the preservative effects of Celsior solution and modified blood Wallwork solution in lung transplantation. METHODS: From 1989 to 2000, 44 lung transplantations for cystic fibrosis were performed: 26 grafts were preserved with modified blood Wallwork solution and 18 with Celsior solution. RESULTS: Preoperative status of the 2 groups was similar. The ratio of arterial oxygen to fraction of inspired oxygen and the pulmonary vascular resistance on the first postoperative day did not differ significantly between the 2 groups. Early death was 4% (SD, 20%) in the Wallwork group versus 11% (SD, 32%) in the Celsior group (not significant). No death was related to graft failure. The forced expiratory volume in 1 second during the first month after transplantation was 63% (SD, 19%) in the Wallwork group versus 63% (SD, 16%) in the Celsior group (not significant). CONCLUSION: Because the solution does not need to be prepared on site and does not require blood from the donor, Celsior seems better than Wallwork solution for preserving lung grafts.


Subject(s)
Albumins/pharmacology , Chlorides/pharmacology , Cystic Fibrosis/surgery , Disaccharides/pharmacology , Electrolytes/pharmacology , Glutamates/pharmacology , Glutathione/pharmacology , Histidine/pharmacology , Lung Transplantation , Lung/drug effects , Lung/surgery , Mannitol/pharmacology , Organ Preservation Solutions/pharmacology , Phosphoprotein Phosphatases/pharmacology , Propionates/pharmacology , Protein Tyrosine Phosphatases/pharmacology , Female , Humans , Male , Retrospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL
...