ABSTRACT
Interdigital pilonidal sinus of the hand is an occupational hazard in barbers, sheep shearers and cow milkers. We present a case of a subungual pilonidal sinus of the thumb of a dog groomer, complicated by the development of osteomyelitis in the distal phalanx.
Subject(s)
Animal Husbandry , Occupational Diseases/etiology , Pilonidal Sinus/etiology , Adult , Animals , Dogs , Female , Humans , Occupational Diseases/pathology , Occupational Diseases/surgery , Pilonidal Sinus/pathology , Pilonidal Sinus/surgery , ThumbABSTRACT
A malignant rhabdoid tumour of the bladder is reported from a girl aged 6. Detailed immunohistochemical and ultrastructural investigations provide evidence which suggests a histiocytic origin for this controversial neoplasm.
Subject(s)
Histiocytes/pathology , Rhabdomyoma/analysis , Urinary Bladder Neoplasms/analysis , Child , Female , Humans , Immunohistochemistry , Membrane Glycoproteins/metabolism , Microscopy, Electron , Mucin-1 , Rhabdomyoma/etiology , Rhabdomyoma/ultrastructure , Urinary Bladder Neoplasms/etiology , Urinary Bladder Neoplasms/ultrastructure , Vimentin/metabolismABSTRACT
Twenty-seven patients undergoing carotid endarterectomy (21 M, 6 F), with a mean age of 62 years, were studied by carotid ultrasound imaging, angiography, and histological examination of endarterectomy specimens, including Perl's stain to detect haemorrhage more than a week old. Haemorrhage into a plaque was seen histologically in 21 patients (78%), compared with 19 (70%) diagnosed preoperatively as echolucent heterogeneous plaques on ultrasound imaging. The remainder were echogenic homogeneous, fibrous plaques. In only one case was the nature of the plaque diagnosed by contrast arteriography. Excised endarterectomy specimens were inspected independently of the ultrasound assessment to determine whether the site of haemorrhage communicated with the base of an atherosclerotic ulcer. Communicating haemorrhages were present in 9 of 11 with episodic symptoms and non-communicating haemorrhages in 7 of 10 patients with a single cerebrovascular event. Perl's stain showed recent haemorrhage in 7 of 11 patients with multiple symptoms, and old haemorrhage in 9 of 10 patients with a single event. These findings suggest that ultrasonically heterogeneous communicating carotid plaques are symptomatically more active than homogeneous non-communicating plaques.
Subject(s)
Arteriosclerosis/diagnosis , Brain Ischemia/diagnosis , Carotid Artery, Internal/pathology , Cerebral Hemorrhage/diagnosis , Ultrasonography/methods , Adult , Aged , Arteriosclerosis/pathology , Brain Ischemia/pathology , Cerebral Hemorrhage/pathology , Endarterectomy , Female , Humans , Ischemic Attack, Transient/diagnosis , Ischemic Attack, Transient/pathology , Male , Middle Aged , Prospective StudiesABSTRACT
Fibrocystic disease of the breast in middle-aged women characteristically shows focal epithelial lesions of a very varied nature. The functional immunohistochemical changes in such lesions have been little studied. Focal Pregnancy-like Change in the breast has a striking morphological similarity to the secretory breast lobules in pregnancy and in lactation. We show that the epithelial cells in all the lesions of Focal Pregnancy-like Change studied simultaneously express secretory component, Ig A and J chain in their cytoplasm. Additionally these epithelial cells, unlike those in resting breast lobules, contain lysozyme and lactoferrin. All these phenotypic immunohistochemical changes in Focal Pregnancy-like Change resemble the breast lobules of late pregnancy and lactation. Possibly, the very focality of Focal Pregnancy-like Change reflects a peculiar and local sensitivity of 'resting' breast lobules to unidentified hormonal stimulation.
