ABSTRACT
Diabetes mellitus is a chronic metabolic disease with an increasing prevalence, caused by a defect in insulin production, insulin action, or both, and can increase the risk for the development of microvascular as well as macrovascular complications. Heat shock protein70 is considered a family of a larger group of proteins known as heat shock proteins, which their expression is induced when the cells are subjected to environmental stress. They are believed to keep the native folding of proteins in cells under stressful conditions and their therapeutic role. Therefore, this study aimed to investigate the serum level of HSP70 in patients with type 2 diabetes mellitus (T2DM) to assess if there is an association of HSP70 with T2DM and to evaluate the effect of age and duration of disease on the serum level of HSP70. Ninety-one patients with T2DM were recruited, and 85 individuals with the same age range and sex as healthy controls. Serum HSP70, fasting blood sugar, and HbA1c were measured. The results revealed that the level of HSP70 was significantly higher in the diabetic group compared to the control group (P value<0.05). The level of HSP70 showed a significant positive correlation with age and duration of disease as well as with fasting blood sugar and HbA1c. The study suggested that HSP70 may have the potential to be used as an indicator of metabolic derangement and a prognostic biomarker in diabetes.
Subject(s)
Diabetes Mellitus, Type 2 , Insulins , Blood Glucose/metabolism , Diabetes Mellitus, Type 2/epidemiology , Glycated Hemoglobin , HSP70 Heat-Shock Proteins/metabolism , Iraq/epidemiology , Humans , Case-Control Studies , Male , Female , Adult , Middle Aged , AgedABSTRACT
The proportion of sickle haemoglobin (HbS) was determined in 170 sickle-cell-trait individuals; 75 (44.1%) individuals had HbS% > 38%, 54 (31.8%) had HbS% between 31% and 38% and 41 (24.1%) had HbS% < 31%. There was positive correlation between HbS% and haemoglobin concentration, packed cell volume, mean corpuscular haemoglobin, mean corpuscular volume and target cell percentage. Multiple regression analysis indicated that measurement of haemoglobin concentration, mean corpuscular haemoglobin and target cell percentage could be used to predict the HbS%.
Subject(s)
Erythrocyte Indices , Hemoglobin, Sickle/metabolism , Hemoglobins/metabolism , Sickle Cell Trait/blood , Sickle Cell Trait/epidemiology , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Genetic Carrier Screening , Genotype , Hemoglobin, Sickle/analysis , Hemoglobins/analysis , Humans , Infant , Iraq/epidemiology , Male , Middle Aged , Population Surveillance , Predictive Value of Tests , Regression Analysis , Sickle Cell Trait/genetics , Urban Health/statistics & numerical dataABSTRACT
The proportion of sickle haemoglobin [HbS] was determined in 170 sickle-cell-trait individuals; 75 [44.1%] individuals had HbS% > 38%, 54 [31.8%] had HbS% between 31% and 38% and 41 [24.1%] had HbS% < 31%. There was positive correlation between HbS% and haemoglobin concentration, packed cell volume, mean corpuscular haemoglobin, mean corpuscular volume and target cell percentage. Multiple regression analysis indicated that measurement of haemoglobin concentration, mean corpuscular haemoglobin and target cell percentage could be used to predict the HbS%
