ABSTRACT
Technetium-99m mercaptoacetyltriglycine (99Tcm-MAG3) was evaluated for the detection and localization of the site of gastrointestinal bleeding in a sheep model. Radioactivity was detected in both the stomach and lower abdomen. However, 99Tcm-MAG3 is partially excreted by the liver and in the bile. The radioactivity in the bile moved to the small bowel. This movement of radioactivity in the lower abdomen can lead to a misinterpretation of the site of bleeding. Hence, 99Tcm-MAG3 may not be an effective radiopharmaceutical for the localization of the site of bleeding in the gastrointestinal tract, particularly the lower abdomen.
Subject(s)
Gastrointestinal Hemorrhage/diagnostic imaging , Oligopeptides , Organometallic Compounds , Technetium , Animals , Disease Models, Animal , Drug Evaluation , Radionuclide Imaging , Sheep , Technetium Tc 99m Mertiatide , Time FactorsABSTRACT
Four Tc-99 radiopharmaceuticals, Tc-99m sulphur colloid, Tc-99m red blood cells (RBCs), Tc-99m mercaptoacetyltriglycine (MAG3), and Tc-99m DTPA, were studied in an experimental animal model for detection and localization of gastrointestinal (GI) bleeding site in both the upper and lower abdomen. With Tc-99m sulphur colloid and Tc-99m RBCs, it was possible to detect and localize the GI bleeding site in the lower abdomen. With Tc-99m MAG3, it was possible to visualize the bleeding site in both the upper and lower abdomen. However, Tc-99m MAG3 is partially excreted by the liver into the bile, hence it will be difficult to use Tc-99m MAG3 to localize the GI bleeding site in the lower abdomen. With Tc-99m DTPA, it was possible to detect and localize the GI bleeding site simultaneously in both upper and lower abdomen. The overall background radioactivity was reduced considerably by diuresis with frusemide and catheterization of the urinary bladder.
