ABSTRACT
Recent advances in magnetic resonance imaging (MRI) have allowed the evaluation of metabolic, diffusion and hemodynamic features of malignant gliomas. The aim of this study was to evaluate whether such information provided useful, complementary information to conventional MRI for improving the evaluation of glioblastoma extent. Ten patients with glioblastoma multiforme underwent conventional MRI, proton MR spectroscopic imaging (1H-MRSI), perfusion-weighted imaging (PWI) and diffusion-weighted imaging (DWI). Metabolite signals, including normalized choline, N-acetylaspartate, creatine and lactate/lipids, were obtained by 1H-MRSI; apparent diffusion coefficient (ADC) by DWI; and relative cerebral blood volume (rCBV) by PWI. In edematous-appearing areas, 3 multiparametric patterns were identified: infiltrating tumor, with abnormal metabolite ratios, lower ADC and higher rCBV; pure edema, with normal metabolite ratios, higher ADC and lower rCBV; and tumor-infiltrated edema, with abnormal metabolite ratios and intermediate ADC and rCBV. In normal-appearing areas, 2 multiparametric patterns were identified: tumor-infiltrated tissue, with abnormal metabolite ratios and higher rCBV; and normal tissue, with normal MR parameters. The combination of 1H-MRSI, DWI and PWI features contributed to delineation of glioblastomas, offering information not available with conventional MRI. This approach may enhance the assessment of brain gliomas, providing useful information for guiding stereotactic biopsies, surgical resection and radiation treatment.
Subject(s)
Brain Neoplasms/diagnosis , Diffusion Magnetic Resonance Imaging/methods , Glioblastoma/diagnosis , Magnetic Resonance Spectroscopy/methods , Edema/etiology , Female , Humans , Male , Middle Aged , PerfusionABSTRACT
A 17-year-old girl affected by Seckel syndrome and multiple intracranial aneurysms is reported. Cerebral hemorrhage was the reason for the diagnostic work-up. The aneurysms were surgically treated. The main features of the syndrome, technical problems encountered during surgery and the prognosis of this condition are discussed.
Subject(s)
Abnormalities, Multiple/genetics , Craniofacial Abnormalities/genetics , Intracranial Aneurysm/genetics , Abnormalities, Multiple/diagnostic imaging , Abnormalities, Multiple/surgery , Adolescent , Brain/abnormalities , Brain/surgery , Cerebral Angiography , Cerebral Hemorrhage/diagnostic imaging , Cerebral Hemorrhage/genetics , Cerebral Hemorrhage/surgery , Chromosome Aberrations/genetics , Chromosome Disorders , Craniofacial Abnormalities/diagnostic imaging , Craniofacial Abnormalities/surgery , Female , Genes, Recessive/genetics , Humans , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/surgery , Postoperative Complications/diagnostic imaging , Reoperation , SyndromeSubject(s)
Brain Abscess/diagnostic imaging , Maxillary Sinusitis/diagnostic imaging , Mucormycosis/diagnostic imaging , Aged , Brain/diagnostic imaging , Brain/pathology , Brain Abscess/etiology , Diabetes Complications , Humans , Magnetic Resonance Imaging , Male , Maxillary Sinus/diagnostic imaging , Maxillary Sinus/pathology , Maxillary Sinusitis/etiology , Mucormycosis/etiology , Tomography, X-Ray ComputedABSTRACT
Intracranial dermoid cysts are usually reported to be associated with long lasting or waxing-waning symptoms. Computer tomography (CT) scans usually depict such neoplasms as well-defined areas of low density. This report is about a case of a dermoid cyst, the acute clinical features and CT hyperdensity of which mimicked a hematoma in the posterior fossa. The association of acute onset with CT hyperdensity makes this case of dermoid cyst very unusual.
Subject(s)
Cerebral Hemorrhage/pathology , Cerebral Ventricle Neoplasms/pathology , Dermoid Cyst/pathology , Hydrocephalus/pathology , Adult , Cerebellum/pathology , Cerebral Hemorrhage/surgery , Cerebral Ventricle Neoplasms/surgery , Dermoid Cyst/surgery , Diagnosis, Differential , Female , Humans , Hydrocephalus/surgery , Tomography, X-Ray ComputedABSTRACT
The authors report their personal series of 100 consecutive surgically treated single brain metastases between 1981 and 1988. Patients selection was decided with respect to general and neurological conditions and to primary cancer development. Resection was mostly radical, postoperative mortality rate was 6% and neurological improvement was obtained in 73% of cases. Mean follow-up was 15 months (min. 12, max. 60). The overall median survival time was 13 months. The survival rate was studied with respect to age, lesion site, preoperative syndrome, primary cancer, cause of death and radiotherapy. On the base of their experience the Authors would stress that a better patients selection can further reduce the mortality rate.
Subject(s)
Brain Neoplasms/secondary , Brain Neoplasms/surgery , Adult , Age Factors , Aged , Brain Neoplasms/mortality , Brain Neoplasms/pathology , Cause of Death , Female , Humans , Male , Middle Aged , Retrospective Studies , Survival RateABSTRACT
Intracerebral hematoma associated with carotid-cavernous fistula is a rare occurrence. Based on a review of the literature and on the analysis of personal observation, the authors define as "high-risk fistula" a carotid-cavernous fistula at risk of intracerebral hemorrhage. Characteristic features of these are computed tomography demonstration of parenchymal vermicular enhancement of brain vessels, and an angiographic pattern of dilated and tortuous cerebral veins. When an intracerebral hemorrhage occurs in a patient with carotid-cavernous fistula an early but phased and combined neuroradiological-neurosurgical approach is suggested as the best way to treat this life-threatening situation.
