Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Vaccine ; 24(23): 5056-63, 2006 Jun 05.
Article in English | MEDLINE | ID: mdl-16621200

ABSTRACT

The treatment effect against psoriasis of an antigen (delipidated, deglycolipidated form of M. vaccae-PVAC) was investigated. One hundred and sixty-five patients were enrolled in three arms (50 or 15 microg or placebo), each receiving a total of two intradermal injections (days 0 and 21). At week 12, a 75% decrease in psoriasis area and severity index was similar among the studied groups (13, 9 and 18%, p=0.429). The overall incidence of adverse events was significantly higher in the PVAC treated groups when compared to placebo (98.2, 87.3 and 70.9%; p<0.001) largely due to local reactions that were limited for the most part to grades 1 and 2 in severity and were self-limiting. Despite its overall safety, PVAC was not clearly indicated to be superior to placebo in the treatment of psoriasis in this study.


Subject(s)
Bacterial Vaccines/therapeutic use , Immunotherapy, Active , Mycobacterium/immunology , Psoriasis/drug therapy , Adolescent , Adult , Aged , Antigens, Bacterial/genetics , Antigens, Bacterial/therapeutic use , Bacterial Vaccines/adverse effects , Female , Humans , Male , Middle Aged , Mycobacterium/genetics , Placebos , Vaccines, Inactivated/adverse effects , Vaccines, Inactivated/therapeutic use
SELECTION OF CITATIONS
SEARCH DETAIL
...