ABSTRACT
HBV is a hepatotropic virus with multiple genotypes. It is uncertain if specific genotype(s) influence virological measures and/or liver markers over time. It is unclear whether nucleos(t)ide analogue therapy response is influenced by genotype. In this retrospective longitudinal study, we utilized data from The Ottawa Hospital Viral Hepatitis Program (TOHVHP) to evaluate the role of HBV genotype on viral load, liver enzymatic levels, fibrosis progression, and parenchymal inflammation and steatosis over time. HBV DNA, ALT, and AST levels, as well as transient elastography scores for fibrosis (E) and inflammation/steatosis (CAP), were modeled using mixed-effects linear regression. Interaction terms between HBV genotype and time were included to investigate if there was a difference in trends between genotypes. A total of 393 HBV patients infected with genotypes A-E were included. The mean age was 44.4 years, and 56% were male. Asian (50.5%), Black (29.1%), and White (6.4%) patients were well-represented. By multivariate analysis, we found no evidence that the trajectories of these commonly measured viral or liver measures varied over time by HBV genotype in those receiving HBV nucleos(t)ides and in those not on antiviral therapy.
ABSTRACT
This research aims to understand the influence of bodily practices, especially gymnastics, in the construction of representations of a healthy body conveyed in a Brazilian women's magazine in the 1940s and 1950s. We use records from the Jornal das Moças magazine for the analysis based on the theoretical and methodological assumptions of cultural history. The results show that gymnastics for women was linked to body maintenance and used as a tool for establishing a body standard, thus disciplining and shapingthe construction of women's health concepts, determined by the aesthetic bias of that period: a slim body as an ideal standard of beauty and health.
