ABSTRACT
Due to growing concern about air pollution and its harmful effects on the health of the population, especially in regard to sub-micrometric particles, some studies have reported that applying an electric field to particle suspensions can improve filter performance by enhancing the deposition of particles in the filter medium. This can result in better particulate retention, which is particularly important for industrial processes such as cement production. The objective of this study was to investigate the behavior of cement particles with electrostatic charges during cake formation in fabric filters. The particles (with a d50 % of 17 µm) were generated using a dust feeder at a flow rate of 0.083 kg s-1. The fiberglass filter medium was subjected to filtration tests with constant dust concentrations (9-12 g.m-³) and air surface velocities (6 cm.s-1and 10 cm s-1) until the pressure drop reached the maximum value of 400 Pa. The electrostatic precipitator utilized discharge voltages of 0, 4, 10, and 12 kV. The particles were initially passed through the electrostatic precipitator to become charged with voltages of 0, 4, 10, and 12 kV applied. The results indicated a reduction in pressure drop of up to 55 %. The study observed a change in the deposition behavior of particles on the filter medium surface and in the filter cake formation, demonstrating that the electrostatic charge improves air filtration performance, resulting in higher efficiency and cost-effectiveness.
ABSTRACT
Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid precursor of serotonin and melatonin. It has been suggested that IDO is the link between the immune and serotonergic systems. This study aimed to quantify the levels of IDO and pro-inflammatory and anti-inflammatory cytokines in patients with MS and depression, according to treatment with interferon-beta (IFN-ß) or fingolimod. The study inclusion criteria were age 18-60 years and a clinical and radiological diagnosis of MS. One hundred and thirty-two patients diagnosed by McDonald's criteria and followed up at Brasília District Hospital, Brazil, with relapsing-remitting MS were identified as potential study participants. Thirty-five of these patients were identified to be receiving treatment with fingolimod or IFN-ß and to have a diagnosis of D/A. IDO and pro-inflammatory and anti-inflammatory cytokine levels were compared between these 35 patients and 18 healthy controls. The level of IL-10 (an anti-inflammatory cytokine) was lower in both the fingolimod-treated (P â< â0.001) and IFN-ß-treated (P â< â0.01) patient groups than in the control group. IFN-ß-treated patients showed increased IDO expression and decreased inflammatory cytokine levels. In contrast, fingolimod-treated patients showed significantly decreased expression of IDO and significantly increased levels of proinflammatory cytokines produced by innate immune cells, including tumor necrosis factor-alpha and interleukin-6. The agents used to treat MS maintain symptoms of D/A in patients with MS via different mechanisms.
ABSTRACT
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor with an important role in the glucose metabolism and a target for type 2 diabetes mellitus therapy. The recent findings relating the use of the receptor full agonist rosiglitazone and the incidence of myocardial infarction raised concerns regarding whether receptor activation can actually be useful for diabetes management. The discovery of MRL-24 and GQ-16, ligands that can partially activate PPARγ and prevent weight gain and fluid retention, showed that a submaximal receptor activation can be a goal in the development of new ligands for PPARγ. Additionally, two previously described receptor antagonists, SR-202 and BADGE, were also shown to improve insulin sensitivity and decrease TNF-α level, revealing that receptor antagonism may also be an approach to pursue. Here, we used a structure-based approach to screen the subset 'Drugs-Now' of ZINC database. Fifteen ligands were selected after visual inspection and tested for their ability to bind to PPARγ. A benzoimidazol acetate, a bromobenzyl-thio-tetrazol benzoate and a [[2-[(1,3-dioxoinden-2-ylidene)methyl]phenoxy]methyl]benzoate were identified as PPARγ ligands, with IC50 values smaller than 10µM. Molecular dynamic simulations showed that the residues H323, H449, Y327, Y473, K367 and S289 are key structural elements for the molecular recognition of these ligands and the polar arm of PPARγ binding pocket.
