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Dissemination of Multidrug-Resistant Proteus mirabilis Clones Carrying a Novel Integron-Borne bla_IMP-1 in a Tertiary Hospital.

Ramos, Ana Carolina; Cayô, Rodrigo; Carvalhaes, Cecilia Godoy; Jové, Thomas; da Silva, Greice Pereira; Sancho, Fernanda Maciel Paschoin; Chagas-Neto, Thomas; Medeiros, Eduardo Alexandrino Servolo; Gales, Ana Cristina.

Antimicrob Agents Chemother ; 62(2)2018 02.

Article in English | MEDLINE | ID: mdl-29158274

ABSTRACT

This study aimed to characterize multidrug-resistant Proteus mirabilis clones carrying a novel class 1 integron-borne blaIMP-1 In1359 was inserted into a large conjugative plasmid that also carried blaCTX-M-2 The production of carbapenemases in Enterobacteriaceae that are intrinsically resistant to polymyxins and tigecycline is very worrisome, representing a serious challenge to clinicians and infection control teams.

Subject(s)

Gene Expression Regulation, Bacterial , Integrons , Plasmids/chemistry , Proteus mirabilis/genetics , beta-Lactamases/genetics , Anti-Bacterial Agents/pharmacology , Brazil/epidemiology , Carbapenems/pharmacology , Clone Cells , Drug Resistance, Multiple, Bacterial/genetics , Humans , Microbial Sensitivity Tests , Plasmids/metabolism , Polymyxins/pharmacology , Proteus Infections/drug therapy , Proteus Infections/epidemiology , Proteus Infections/microbiology , Proteus Infections/transmission , Proteus mirabilis/drug effects , Proteus mirabilis/enzymology , Proteus mirabilis/isolation & purification , Tertiary Care Centers , Tigecycline/pharmacology , beta-Lactamases/metabolism

ABSTRACT

Subject(s)

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