1.
Eur J Med Chem
; 47(1): 52-8, 2012 Jan.
Article
in English
| MEDLINE
| ID: mdl-22071254
ABSTRACT
A series of 2,5-diaryl substituted furans functionalized with several amino acids were synthesized and evaluated as the cyclooxygenases COX-1 and COX-2 enzymes inhibitors. The proline-substituted compound inhibited PGE(2) secretion by LPS-stimulated neutrophils, suggesting selectivity for COX-2. Molecular docking studies in the binding site of COX-2 were performed.