ABSTRACT
Rheumatoid arthritis (RA) is a systemic autoimmune disease that impairs mobility. How does sensory information influence postural responses in people with RA? The aim of this study was to evaluate the postural control of people with RA during a sensory organization test, comparing how sensory information influences postural responses in people with rheumatoid arthritis compared with healthy people. Participants were 28 women with rheumatoid arthritis (RA group) and 16 women without any rheumatoid disease (Control group CG). The Sensory Organization Test (SOT) was performed on a Smart Balance Master® (NeuroCom International, Inc., Clackamas, OR, USA) and center of pressure (COP) was measured. SOT conditions: SOT1 (eyes open, fixed support surface and surround; SOT2) eyes closed, fixed support surface and surround; and SOT5) eyes closed, sway-referenced support surface, and fixed surround. To compare the demographic and clinical aspects between groups, independent t-test or Mann-Whitney's U-test were used. Differences were found between groups. Between SOT conditions, for CG and RA, COP was faster for SOT-5 than SOT-1, while SOT-1 and SOT-2 presented similar COP velocity. For SOT-2 and SOT-5, COP was larger for the RA group. For both groups, SOT-1 presented the smallest COP, and SOT-5 showed the largest COP.
Subject(s)
Musculoskeletal Manipulations , Postural Balance , Humans , Female , Postural Balance/physiology , Physical Therapy Modalities , Control GroupsABSTRACT
The association between chronic kidney disease (CKD) and pulmonary pathophysiological changes is well stablished. Nevertheless, the effects of aerobic exercise (AE) on lungs of CKD need further clarification. Thus, Swiss mice were divided in control, AE, CKD, and CKD + AE groups. CKD was induced by 0.2% adenine intake during 8 weeks (4 weeks of CKD induction and 4 weeks of AE). AE consisted in running on treadmill, at moderate intensity, 30 min/day, 5 days/week, during 4 weeks. Twenty-four hours after the last training day, functional capacity test was performed, and 48 h after the test, mice were euthanized. CKD mice showed a significant increase in urine output, serum urea, and creatinine concentrations, and decreased body weight and urine density, besides oxidative damage (p = 0.044), edema area (p < 0.001), leukocyte infiltration (p = 0.040), and collagen area in lung tissue (p = 0.004). AE resulted in an increase of distance traveled (p = 0.049) and maximum speed (p = 0.046), increased activity of catalase (p = 0.031) and glutathione peroxidase (p = 0.048) in lungs, increased levels of nitric oxide (NOx) in serum (p = 0.001) and bronchoalveolar lavage fluid (p = 0.047), and decreased kidney histological injury (p = 0.018) of CKD mice. However, AE also increased oxidative damage (p = 0.003) and did not change collagen content or perivascular edema in lungs (p > 0.05) of CKD mice. Therefore, AE attenuated kidney injury and improved antioxidants defenses in lungs. Despite no significant changes in pulmonary damage, AE significantly improved physical performance in CKD mice.
Subject(s)
Antioxidants , Renal Insufficiency, Chronic , Adenine/pharmacology , Animals , Antioxidants/pharmacology , Catalase/metabolism , Creatinine , Glutathione Peroxidase , Kidney/pathology , Lung/metabolism , Mice , Nitric Oxide , Oxidative Stress , Physical Functional Performance , Renal Insufficiency, Chronic/chemically induced , Renal Insufficiency, Chronic/pathology , Urea/pharmacologyABSTRACT
Caracterizar os aspectos sociodemográficos, clínicos e a qualidade de vida (QV) de pacientes com artrite reumatoide (AR). Métodos: Tratou-se de um estudo transversal e descritivo, com abordagem quantitativa. Avaliou-se 22 indivíduos com AR, independentemente do sexo, e com idade superior a 18 anos. Os participantes foram encaminhados para o Laboratório de Análise Multissetorial da Universidade Estadual de Santa Catarina por médicos reumatologistas vinculados ao Sistema Único de Saúde, no período de junho a setembro de 2010. Utilizou-se uma ficha de avaliação para levantamento dos aspectos sociodemográficos e clínicos, nível de atividade da doença (Disease Activity Score 28) e o Questionário de Qualidade de Vida (36 Item Short-Form Health Survey). Resultados: Houve predomínio do sexo feminino, com 81,8% (n=18); etnia branca, com 90,9% (n=20); e da sexta década de vida, com 60,0 (±12,90) anos no sexo masculino. Dentre os sintomas, 17 (77,3%) indivíduos referiram dor como a principal queixa. No nível de atividade da doença, verificou-se que os valores médios foram 4,4 (±1,56), com predomínio de 10 (45,5%)indivíduos em atividade moderada. Na QV, evidenciou-se diferença significativa no domínio dor e aspecto social em função do nível de atividade da doença (p<0,05). No domínio dor, houve diferença significativa quando comparado os grupos alta e baixa atividade da doença (p<0,01) e entre os grupos baixa e moderada (p<0,01). Conclusão: Pôde-se identificar, nos indivíduos com artrite reumatoide participantes do estudo, prejuízo no seu estado geral de saúde e, além disso, o elevado nível de atividade da doença interferiu na sintomatologia dolorosa e comprometeu o aspecto social...
To characterize the sociodemographic clinical aspects and quality of life ofpatients with rheumatoid arthritis (RA). Methods: This was a descriptive, cross-sectional quantitative research that evaluated 22 individuals with RA over 18 years old, regardless of sex. Participants were referred to the Mulstisectoral Analysis Laboratory of the State University of Santa Catarina by rheumatologists of the Brazilian National Health System in the period from June to September 2010. It was used a form to obtain sociodemographic and clinical data, the level of disease activity (Disease Activity Score 28) and the Quality of Life Questionnaire (36 Item Short-Form Health Survey). Results: There was a prevalence of female gender, with 81.8% (n=18); white ethnicity, with 90.9% (n=20); and sixth decade of life, with 60 (±12.9) years for male gender. Among the symptoms, 17 individuals (77.3%) reported pain as the main complaint. Regarding the level of disease activity, the mean values were 4.47±1.56 with a prevalence of 10 patients (45.5%) presenting moderate activity. Concerning QoL, it was found a significant difference in the domains pain / social aspect and the level of disease activity (p <0.05). Regarding the domain pain, there was a significant difference when comparing the groups high and low disease activity (p<0.01) and between the low and moderate groups (p <0.01). Conclusion: It was possible to identify in the individuals with RA participating in this study a deficit in their general state of health. Additionally, the high level of disease activity interfered with painful symptomatology and hindered social aspects...
Caracterizar los aspectos sociodemográficos, clínicos y la calidad de vida (CV) de pacientes con artritis reumatoide (AR). Método: Se trató de un estudio transversal y descriptivo de abordaje cuantitativo. Se evaluó 22 individuos con AR independiente del sexo y de edad superior a 18 años. Los participantes fueron encaminados al Laboratorio de Análisis Multisectorial de la Universidad Provincial de Santa Catarina por médicos reumatólogos vinculados al Sistema Único de Salud en el período entre junio y septiembre de 2010. Se utilizó una ficha de evaluación para recogida de los aspectos sociodemográficos y clínicos, nivel de actividad de la enfermedad (Disease Activity Score 28) y el Cuestionario de Calidad de Vida (36 Item Short-Form Health Survey). Resultados: Hubo predominio del sexo femenino en el 81,8% (n=18); etnia blanca en el 90,9% (n=20); y de la sexta década de vida, con 60,0(±12,9) años en el sexo masculino. De los síntomas, 17 (77,3%) individuos relataron dolor como queja principal. A nivel de actividad de la enfermedad se verifico que los valores medios fueron 4,47±1,56, con predomínio de 10 (45,5%) individuos con actividad moderada. Respecto la CV se evidenció diferencia significativa en el dominio dolor y aspecto social en función del nivel de actividad de la enfermedad (p<0,05). Hubo diferencia significativa en el dominio dolor al comparar los grupos alta y baja actividad de la enfermedad (p<0,01) y entre los grupos baja y moderada actividad (p<0,01). Conclusión: Se pudo identificar en los individuos con artritis reumatoide que participaron en el estudio, perjuicio del estado general de salud y además el nível elevado de actividad de la enfermedad influyó em los síntomas de dolor y en el aspecto social...
