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Nat Prod Res ; 35(12): 2056-2059, 2021 Jun.
Article in English | MEDLINE | ID: mdl-31401870

ABSTRACT

The aerial parts of L. cultratus were submitted to a phytopharmacological investigation in order to isolate and identify the major secondary metabolites and evaluate its crude extract, fractions and isolated compounds for antiproliferative activity. Seven compounds were isolated and identified as the chalcones 2',4'-dihydroxy-5'-prenylchalcone (1) and isocordoin (2), the flavanone 8-prenylpinocembrin (3), the alkaloid 4-hydroxy-N-methylproline (4), the triterpenes lupeol and lupenone. These compounds were identified by nuclear magnetic resonance of 1H and 13C data in comparison with literature. Hexanic fraction and chalcone 2',4'-dihydroxy-5'-prenylchalcone showed potent results against human cancer cell lines tested.


Subject(s)
Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Fabaceae/chemistry , Catechols/chemistry , Catechols/pharmacology , Cell Proliferation/drug effects , Chalcones/chemistry , Chalcones/isolation & purification , Chalcones/pharmacology , Drug Screening Assays, Antitumor , Fabaceae/metabolism , Humans , K562 Cells , Magnetic Resonance Spectroscopy , Molecular Structure , Pentacyclic Triterpenes/chemistry , Pentacyclic Triterpenes/pharmacology , Plant Extracts/chemistry , Plant Extracts/pharmacology , Plants, Medicinal/chemistry , Plants, Medicinal/metabolism , Secondary Metabolism , Triterpenes/chemistry , Triterpenes/pharmacology
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