Clinical and oral findings in an Afro-Brazilian family with Gorlin-Goltz syndrome: case series and literature review.

Gorlin-Goltz syndrome (GGS) seems to be unusual in black persons. The authors present an Afro-Brazilian family case report of GGS. The main complaint of the index case was a painless swelling of the left mandible, which was diagnosed as an odontogenic keratocyst. Further classical features of the Syndrome were present in this patient. Other two family members were diagnosed as cases of GGS and one of them presented 11 clinical findings characteristic of the syndrome. From the three cases reported, two of them presented five major diagnostic criteria for the GGS, and the diagnosis was only made because of an oral complaint. This case series emphasizes the importance of carefully examining the patient and close relatives for signs of GGS, even if they belong to an ethnic group in which this diagnosis is unusual.

Evaluation of inflammatory response of EDTA, EDTA-T, and citric acid in animal model.

INTRODUCTION: The biocompatibility of chelating agents and organic acids have been explained by a variety of methods, and suggestions for use have been based more on clinical observations and physicochemical properties than on biological aspects. The present study aimed to evaluate the inflammatory response of 17% EDTA, 17% EDTA-T, and 10% citric acid in bony defect created in rat jaws. METHODS: Mandibular through and through critical size defects were created bilaterally in 60 rats. Fibrinol (Baldacchi SA, São Paulo, Brazil), a cube-shaped compound of absorbable bovine fibrin foam and sodium chloride, was used as a carrier of the substances. One side had received Fibrinol (control), whereas the opposite side had received Fibrinol soaked with each substance on the 1st, on the 7th, on the 14th, and on the 28th day (n=5 for each day). Hemijaws were prepared for light microscopy, and samples were stained with hematoxylin and eosin. Digitized images were analyzed with a morphometric software (ImageJ; National Institute of Mental Health, Bethesda, MD). to obtain the number of inflammatory cells per area. Comparisons were performed by using the Kruskal-Wallis test (p=0.05). RESULTS: For all days, 10% citric acid and 17% EDTA-T showed, respectively, the lowest and highest number of inflammatory cells per area. All tested substances and controls showed the highest inflammatory cell response on the 14th day. CONCLUSION: Among the tested substances, 10% citric acid proved to be the less aggressive tested solution at 14 days. At 28 days, all solutions were similar, but EDTA-T kept showing the higher number of inflammatory cells.

Pediatricians' perception about the use of antibiotics and dental caries--a preliminary study.

OBJECTIVES: This study aimed to evaluate pediatricians' perception about the use of antibiotics and dental caries. METHODS: One hundred pretested questionnaires containing open and closed questions were distributed to pediatricians from public hospitals in Rio de Janeiro, Brazil. RESULTS: The response rate was 60 percent. Considering the respondents, 73.3 percent frequently prescribed antibiotics, oral administration being the chosen mode (93.3%). Antibiotics were pointed out as being very sweet substances by 53.3 percent of the pediatricians. However, the same percentage did not know what sweetener was responsible for the sweet flavor, and just 40.6 percent recommended oral hygiene after the medicine's intake. Among the pediatricians, 56.7 percent related the use of antibiotics to the occurrence of dental effects, and 40 percent thought that antibiotics could cause a defect of tooth structure. Only one pediatrician (3.2%) associated the presence of fermentable carbohydrates in the composition of these medicines with dental caries. CONCLUSIONS: Pediatricians in this study did not perceive the correct relationship between the presence of fermentable carbohydrates in antibiotics and dental caries. Many of them believed these medicines promoted a defect of tooth structure favoring the development of dental caries. Further studies with a larger sample are necessary.