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1.
Indian J Radiol Imaging ; 23(2): 126-33, 2013 Apr.
Article in English | MEDLINE | ID: mdl-24082476

ABSTRACT

BACKGROUND AND STUDY AIMS: Our aim was to assess the efficacy and tolerability of drug-eluting beads-transarterial chemoembolization (DEB-TACE) in the treatment of hepatocellular carcinoma (HCC), evaluating the response to the treatment after 1, 6, 12, and 24 months with multidetector computed tomography (MDCT) comparing European Association for the study of the Liver (EASL) and modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria. MATERIALS AND METHODS: We enrolled 154 patients with uni- or multifocal HCC who underwent a DEB-TACE. A total of 278 HCC nodules were treated. CT follow-up was performed at 1, 6, 12, and 24 months after the procedure according to the EASL and RECIST criteria evaluating overall target and target nodule response. We also analyzed the shrinking of nodules in relation to response to treatment. RESULTS: A total of 278 nodules of HCC underwent TACE by using DC-Beads: At 24, months complete response was similar for EASL and RECIST criteria (112 vs. 121 nodules) with optimal accordance between methods and readers with k = 0.9. Partial Response resulted significantly different among the two methods within the first month, otherwise was similar after 24-month follow-up. Similar results in both methods were found for nodules classified as Stable Disease (P > 0.05). Progressive Disease results were similar in both the groups according to both the classification criteria without any significant difference (P > 0.05). CONCLUSION: Our study confirmed that EASL and mRECIST criteria are both effective methods for patient follow-up, however with some technical differences.

2.
Cardiovasc Intervent Radiol ; 29(5): 893-6, 2006.
Article in English | MEDLINE | ID: mdl-16328684

ABSTRACT

A 75-year-old man with arterial hypertension, coronary artery disease, and myocardial infarction was referred to our service because of an asymptomatic hypogastric artery aneurysm (HAA) detected by a routine computed tomography (CT) scan. As shown on the angio-CT the maximum transverse diameter (m.t.d.) of the HAA was 47 mm. There were no symptoms of distal embolization or compression on the pelvic structures. We performed the successful complete thrombosis of the aneurysm using vascular plugs via a controlateral femoral approach. The control angiogram was satisfactory and there were no intraoperative complications. A CT-angiography done 4 months after the procedure showed no signs of refilling of the aneurysm sac. This case illustrates some possible advantages of vascular plugs in the treatment of isolated HAA.


Subject(s)
Embolization, Therapeutic , Iliac Aneurysm/therapy , Aged , Angiography , Humans , Iliac Aneurysm/diagnostic imaging , Male , Tomography, X-Ray Computed
3.
Radiol Med ; 110(4): 359-69, 2005 Oct.
Article in English, Italian | MEDLINE | ID: mdl-16292243

ABSTRACT

PURPOSE: We report our experience with the percutaneous treatment of superior vena cava syndromes of benign etiology. MATERIALS AND METHODS: From August 1994 to August 2003 a total of 14 superior vena cava syndromes of benign origin were treated. Previous use of a central venous catheter pending the development of a peripheral arteriovenous fistula for dialysis was believed to be the cause of the obstruction of the superior vena cava in 11 patients. In 2 other cases the cause was attributed to post-radiation mediastinal fibrosis and, in one case, to a previously implanted pacemaker. The superior vena cava syndrome was confirmed by venography. After negotiating the obstruction, a self-expanding stent was selected based on the CT and venographic data. At the end of the procedure, technical success was confirmed by venography, and haemodynamic success by pressure measurements. The follow-up allowed the assessment of the clinical success of the procedure. RESULTS: Technical success was achieved in 13 patients (92.8%); in one case the obstruction could not be negotiated with the wire guide, so the patient was referred for surgery. One self-expanding stent proved sufficient to resolve the central venous obstruction and restore superior vena cava diameter in all cases but one. In one young woman, whose central obstruction was resolved with PTA, was unable to complete the procedure with deployment of a self-expanding stent owing to a supervening asthma attack that could not be treated with the commonly-used drugs. No complications related to the procedure were reported. The symptoms cleared up within 2 weeks, and haemodynamic improvements were already seen within minutes of stent deployment. CONCLUSIONS: Percutaneous treatment is a valuable alternative to surgery as it is able to restore haemodynamic parameters and resolve the clinical picture, ensuring longer functionality to arteriovenous fistulae and an improved quality of life.


Subject(s)
Angioplasty, Balloon , Stents , Superior Vena Cava Syndrome/therapy , Adult , Aged , Female , Humans , Male , Middle Aged , Radiography, Interventional , Superior Vena Cava Syndrome/diagnostic imaging
4.
Radiol Med ; 107(3): 241-51, 2004 Mar.
Article in English, Italian | MEDLINE | ID: mdl-15031689

ABSTRACT

PURPOSE: To report our experience in the control of haemorrhage with the transcatheter embolisation technique. MATERIALS AND METHODS: Between 1999-2001, we treated 56 patients with important pelvic trauma. Forty-two were victims of car accidents and 14 of falls from great altitudes. Twenty presented acute symptoms due to blunt pelvic trauma, with massive bleeding, not treatable by drugs and blood transfusion. Diagnosis of pelvic haemorrhage was made with CT. When high-flow haemorrhage was found, the patient was referred for angiography. Embolisation was achieved after a diagnostic arteriography, with bilateral transfemoral approach and selective catheterisation of the internal iliac arteries. RESULTS: Technical success was achieved in 100% of cases: all the haemorragic sites were found and embolised. In only one patient with severe shock was it impossible to locate the site of contrast material extravasation on the first day; the patient was successfully treated on the second day with improvement of the clinical conditions. The obturator artery was involved in five cases, the gluteal artery in eleven. In eighteen patients, use of an angiographic catheter was sufficient to treat the haemorragic sites. Percutaneous control of the haemorrhage was obtained by using Gelfoam, Ivalon and coils. CONCLUSIONS: Percutaneous haemorrhage control is safe and effective, and not as costly or dangerous as the surgical option. We regard it as the treatment of choice in multiple trauma patients with important and high-flow pelvic haemorrhage.


Subject(s)
Embolization, Therapeutic , Fractures, Bone/complications , Hemorrhage/therapy , Pelvic Bones/injuries , Radiography, Interventional , Adolescent , Adult , Angiography , Female , Hemorrhage/etiology , Humans , Male , Middle Aged , Treatment Outcome
5.
Radiol Med ; 106(3): 221-31, 2003 Sep.
Article in English, Italian | MEDLINE | ID: mdl-14612843

ABSTRACT

PURPOSE: Male varicocele affects children with the same incidence as it does adults. The association between asymptomatic idiopathic varicocele and male infertility and the poor recovery of testicular function after varicocele repair in adulthood have called for noninvasive clinical and instrumental diagnosis and increasingly early treatment. The department of Pediatric Surgery at our Hospital has screened schoolchildren for the early diagnosis and treatment of childhood varicocele. Our Vascular and Interventional Radiology department has proposed percutaneous treatment for varicocele correction. We report our 10-year experience with percutaneous sclerotherapy of pediatric varicocele with a retrograde transbranchial approach. MATERIALS AND METHODS: From a screening programme involving schools 467 boys were selected who were positive for idiopathic varicocele at clinical examination and at Doppler CW, at rest and during Valsalva manoeuvre. Patients with grade III, or symptomatic grade II varicocele, testicular hypotrophy, or with a dilation of the testicular veins greater than 2.2 mm at baseline were referred for percutaneous treatment. Percutaneous treatment was performed with a transbrachial approach in the basilic vein. After searching for incontinence of the internal right spermatic vein, left renal phlebography was performed in order to identify any incontinence of the left spermatic vein. This vein was then selectively catheterised to perform sclerosis. Tungsten coil embolisation was also performed over a number of years. Follow-up consisted of clinical examination, Doppler CW, Doppler US, or colour Doppler US performed at 3, 6, and 12 months. RESULTS: The radiological procedure was only diagnostic in 78 cases (16.7%). Basilic vein spasm and collaterally-supplied varicocele forced us to discontinue the procedure. The use of materials with smaller diameters and the professional development of the radiological team helped improve the catheterisation rate with time. Using the transbrachial approach alone a total of 287 left-sided, 15 right-sided and 52 bilateral varicoceles were treated. Whereas in two cases of bilateral varicocele a dissection at the origin of both spermatic veins prevented the use of sclerotherapy--though the patients were found to be cured at follow-up with Doppler US--on the left the procedures were continued with a transfemoral approach due to difficulties with the transbrachial catheterisation. As for the left-sided varicoceles, sclerosis were performed in 230 procedures, whereas sclerosis and embolisation on 87 patients. The success rate was 92% for sclerosis, and 86% for sclerosis and embolisation. No major complications were observed. DISCUSSION: Percutaneous treatment is a minimally invasive and relatively non-traumatic interventional radiology procedure, able to confirm the presence of varicocele, accurately map the venous system and allow selective therapy. Our experience with 467 patients over 10 years has allowed us to compare two therapeutic options: sclerosis and sclerosis combined with embolisation. CONCLUSIONS: Percutaneous treatment of varicocele with the transbrachial approach proved to be a safe, effective, inexpensive, and minimally invasive procedure. It can be suggested as the first therapeutic option for varicocele correction, especially for boys and for bilateral forms.


Subject(s)
Varicocele/therapy , Adolescent , Catheterization , Humans , Male , Mass Screening , Phlebography , Varicocele/diagnostic imaging
6.
Radiol Med ; 105(5-6): 462-70, 2003.
Article in English, Italian | MEDLINE | ID: mdl-12949457

ABSTRACT

PURPOSE: Epididymal cysts are benign structures commonly seen during urological or ultrasound testicular examinations. They are treated only if symptomatic. Surgery is the standard treatment, although it carries a high risk of complications. We report our experience with sclerotherapy of epididymal cysts with sonographic assistance, and present an analysis of costs. MATERIALS AND METHODS: Between January 1999 and December 2000 we examined 48 epididymal cysts in 45 patients during ultrasound examinations. Except one, all of the patients were symptomatic. We decided to treat 25 symptomatic cysts that were more than 5 cm. in diameter. All of the patients refused surgery as they knew of the existence of the percutaneous method. The procedures were performed on a out-patient basis with ultrasound assistance and using 3% Polidocanol for sclerosis. Follow-up was at 3/6 and 12 months after treatment. If we found persistence of symptoms and/or a cyst was more than 5 cm of diameter, a second session was proposed. RESULTS: Twenty-five epididymal cysts were treated, with a technical success of 100%. Mean fluid evacuation was 36 ml; mean sclerosing agent injected was 4.5 ml. There were no complications. After 3/6 months 17/25 patients were free of symptoms (68%) and the cysts had disappeared in 15 of them (60%). After the repeat procedure, performed on only 4 patients, the number of symptom-free patients was 21/25 (84%). DISCUSSION: Epididymal cysts are often solitary cystic fluid collections that are occasionally reported during physical or ultrasound urological clinical examinations. They present as painless testicular enlargements on palpation and are echo-free at ultrasound examination. Percutaneous sclerotherapy has gained wide acceptance in the therapeutic handling of other pathologies and it appears as an ideal solution for this benign clinical condition of the superficial structures. Polidocanol, widely used on varicose vein therapies for its local anaesthetic properties, is the ideal sclerosing agent for superficial and delicate structures, such as epididymal cysts. The results of the present study have shown that symptomatic cysts may be cured in 84% of cases without complications and with low costs. CONCLUSIONS: Percutaneous sclerotherapy is a valid therapeutic alternative to surgery in the management of epididymal cysts: it is safe, effective, free of complications, less costly and shows good results in the follow-up.


Subject(s)
Cysts/therapy , Genital Diseases, Male/therapy , Polyethylene Glycols/therapeutic use , Sclerosing Solutions/therapeutic use , Sclerotherapy/methods , Adolescent , Adult , Aged , Aged, 80 and over , Cysts/diagnostic imaging , Genital Diseases, Male/diagnostic imaging , Humans , Male , Middle Aged , Polidocanol , Ultrasonography
7.
Radiol Med ; 105(5-6): 500-10, 2003.
Article in English, Italian | MEDLINE | ID: mdl-12949461

ABSTRACT

PURPOSE: Varicocele is a common clinical condition that affects 15% of the male population and is an important cause of male infertility. Fluoroscopy-guided percutaneous treatment with retrograde sclerosis is a good alternative to surgery. We report our experience in calculating the total radiation dose to patient and the associated risk. MATERIALS AND METHODS: Our study was performed on 67 patients undergoing percutaneous treatment of varicocele with transbrachial approach and retrograde sclerosis. Thirteen dosimeters with two TLD detectors were positioned on the patients' skin. Calculation of the Entrance Surface Dose and application of appropriate transmission coefficients of the depth-dose allowed us to determine the Equivalent Doses for the single organs. Similar studies were conducted during plain abdominal x-ray and urography for comparative purposes. RESULTS: The mean effective dose during percutaneous treatment of varicocele was 18 mSv, whereas the dose for abdominal x-ray was 1.31 mSv and that for urography was 4.6 mSv. DISCUSSION AND CONCLUSIONS: Examinations involving the use of x-rays have been estimated to contribute to half of all the radiation absorbed by the population, and the number of both diagnostic examinations and interventional procedures is steadily rising. Radiation exposure, especially in children, requires special consideration. Percutaneous treatment of varicocele is a valuable alternative to surgery, not least because of reduced exposure. The use of specially-built lead coats and the creation of regional referral centres employing specialised staff are two possible measures that could further reduce radiation doses and dispel concerns about this procedure.


Subject(s)
Radiation Dosage , Radiography, Interventional/methods , Sclerosing Solutions/administration & dosage , Varicocele/therapy , Adolescent , Catheterization, Peripheral/methods , Humans , Male , Monte Carlo Method , Phantoms, Imaging
9.
Radiol Med ; 105(1-2): 56-62, 2003.
Article in English, Italian | MEDLINE | ID: mdl-12700546

ABSTRACT

PURPOSE: To prevent pulmonary embolism, some clinical situations only need a vena cava filter for several days, without the inconveniences of temporary vena cava filters in the short-medium term and without the drawbacks of permanent ones in the long term. We report our initial experience with a new definitive vena cava filter, easy to retrieve when it becomes unnecessary. MATERIAL AND METHODS: From the beginning of January 1999 to December 2001, 18 ALN vena cava filters were deployed. The approach used was transbrachial in ten patients, transjugular in seven, and transfemoral in the others. The indications were pelvic trauma in eleven patients, hip replacement in three; four filters were "prophylactically" placed before surgery in patients at high risk of thromboembolic disease (three with ileal or femoral or ileo-femoral thrombosis, and one without clinically manifest thromboembolic disease). Optional vena cava filters were evaluated for malpositioning, caval perforation, filter migration, acute caval thrombosis or access site thrombosis. Seven optional vena cava filters were retrieved. CT was performed before retrieving the vena cava filters to document the absence of thrombi inside the filters. The transjugular ap-proach was used to retrieve the filters. RESULTS: Technical success was achieved in all patients. No complications were encountered during the procedure; no migration or rupture of the filters was detected during the follow-up. No thrombosis of the vena cava or at the insertion site was encountered. The median retrieval time for the filters was 12': only the transfemoral filters required 15' of fluoroscopy. The median permanence was 63 days. No thrombi were found inside the filters. DISCUSSION: A definitive vena cava filter, easy to retrieve when it becomes unnecessary, is the ideal device in many clinical conditions: young subjects with pelvic fractures orthopaedic and gynaecologic interventions.


Subject(s)
Pulmonary Embolism/prevention & control , Vena Cava Filters , Adult , Aged , Aged, 80 and over , Device Removal , Equipment Design , Female , Humans , Male , Middle Aged , Radiography, Interventional , Tomography, X-Ray Computed , Treatment Outcome
10.
Radiol Med ; 105(1-2): 76-82, 2003.
Article in English, Italian | MEDLINE | ID: mdl-12700549

ABSTRACT

INTRODUCTION: Pelvic congestion syndrome and chronic pelvic pain are enigmatic clinical conditions that may have considerable impact on the social and relational life of women. Patients usually complain of lower abdominal pain that has lasted for more than six months, is intermittent or continuous, and may become worse during menses or after a hard day's work. Sometimes the pain is accompanied by dyspareunia, urinary urgency or constipation. The traditional treatment of pelvic congestion syndrome has included both medical (analgesics, hormones) and surgical approaches (hysterectomy, ovarian vein ligation). Recently, percutaneous transcatheter embolization has also been proposed. We report our experience with the percutaneous management of pelvic congestion syndrome, using the transbrachial approach and sclerosis alone. MATERIAL AND METHODS: Between 1996 and 2001, 33 women underwent percutaneous treatment for pelvic congestion syndrome at our department. All the women had chronic pelvic pain which was continuous in 69%; 20 patients had dyspareunia, whereas 8 had urinary urgency; 72% took analgesics on a regular basis. All the patients underwent percutaneous treatment of pelvic congestion syndrome on a outpatient basis in a radiological suite, after receiving local anaesthesia. Sclerosis was performed with 3% sodium tetradecyl sulfate. Follow-up consisted of a questionnaire at one month and gynaecological and ultrasound examinations at 6/12 months. RESULTS: The pre-procedural ultrasound examination had revealed a mean diameter of 4.5 mm for the right ovarian vein and of 6.3 mm for the left. We found one pelvic congestion syndrome on the right, 11 on the left and 21 bilaterally. At the one-month follow-up, chronic pelvic pain was present in 13 patients (39%); the pain was continuous in three and intermittent in ten. At the follow-up after 6/12 months the symptoms were unchanged. Ultrasound revealed a reduction in periovarian varicosities, recording a mean diameter of 3.19 mm on the right and 4.5 mm on the left. Symptoms persisted in women with pelvic varicosities measuring over 5 mm at ultrasound. CONCLUSIONS: Pelvic congestion syndrome and chronic pelvic pain that do not respond to medical therapy can be resolved by percutaneous management. Less expensive than surgery, this therapeutic option is safe, effective, minimally invasive and capable of restoring patients to normal function. We propose the transbrachial approach as the first-choice treatment for bilateral pelvic congestion syndrome.


Subject(s)
Ovary/blood supply , Pelvic Pain/therapy , Sclerotherapy , Varicose Veins/therapy , Adult , Chronic Disease , Female , Humans , Middle Aged , Pain Measurement , Pelvic Pain/diagnostic imaging , Sclerosing Solutions , Syndrome , Treatment Outcome , Ultrasonography , Varicose Veins/diagnostic imaging
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