Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Type of study
Language
Publication year range
1.
Biomed Pharmacother ; 114: 108797, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30951950

ABSTRACT

OBJECTIVE: To analyze the remodeling dynamics of total collagen, type I and III, the expression of ICAM-1 and 5-HT in the jejunum of rats. METHODS: Twenty-eight Wistar rats were randomly assigned to two experimental groups: the control group (CG, n = 7) and the infected group (receiving 5,000 sporulated T. gondii oocysts - ME49 strain, genotype II, n = 21). Seven infected rats each at 6 (G6), 12 (G12), and 24 (G24) hours post infection were sacrificed and segments of jejunum were collected for standard histological, histochemical, and immunohistochemistry processing techniques. RESULTS: The infection promoted ICAM-1 and 5-HT expression, type III collagen, and total mast cell increases. However, it also caused a reduction in the area occupied by type I collagen fibers, and in submucosa thickness, and caused ganglion and peri-ganglion alterations. CONCLUSION: The structural damage caused by toxoplasmic infection is intense during the first 24 h post inoculation. At peak dissemination, from 12 to 24 h, there is an increase in ICAM-1 and 5-HT expression, with intense migration of mast cells to the site of infection. There was also a reduction in submucosa thickness, and an effective loss of extracellular matrix (ECM) organization, which included changes in the dynamics of type I and III total collagen deposition.


Subject(s)
Intercellular Adhesion Molecule-1/metabolism , Jejunum/metabolism , Jejunum/parasitology , Serotonin/metabolism , Toxoplasma/pathogenicity , Toxoplasmosis/metabolism , Toxoplasmosis/parasitology , Animals , Collagen Type I/metabolism , Collagen Type III/metabolism , Extracellular Matrix/metabolism , Extracellular Matrix/parasitology , Ganglion Cysts/metabolism , Ganglion Cysts/parasitology , Male , Mast Cells/metabolism , Mast Cells/parasitology , Rats , Rats, Wistar
SELECTION OF CITATIONS
SEARCH DETAIL
...