ABSTRACT
A better understanding of biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. In this work, ribs of Wistar rat submitted to radiotherapy simulation were imaged using synchrotron radiation computed microtomography at Elettra Synchrotron Laboratory in Trieste, Italy. Histomorphometric parameters were calculated directly from the 3D microtomographic images and showed significant differences between irradiated and non-irradiated groups.
Subject(s)
Breast Neoplasms/radiotherapy , Disease Models, Animal , Ribs/pathology , Tomography, X-Ray Computed/methods , Animals , Breast Neoplasms/pathology , Female , Rats , Rats, Wistar , SynchrotronsABSTRACT
The research on applications of segmentation algorithms to Synchrotron Radiation X-Ray micro-Computed Tomography (SR-µCT) is an open problem, due to the interesting and well-known characteristics of SR images, such as the phase contrast effect. The Energy Minimization via Graph Cuts (EMvGC) algorithm represents state-of-art segmentation algorithm, presenting an enormous potential of application in SR-µCT imaging. We describe the application of the algorithm EMvGC with swap move for the segmentation of bone images acquired at the ELETTRA Laboratory (Trieste, Italy).
ABSTRACT
PhC-SR-µCT is a nondestructive technique that allows the microanatomical investigations and 3D images reconstructions. This technique is performed in blood sucker, Rhodnius prolixus--one of the most important insect vectors of Trypanosoma cruzi, ethiologic agent of Chagas' disease in Latin America--was able to provide excellent information about the microanatomy of the thorax and head allowing a new tool for further studies of development and physiology of triatomine by a non-invasive method of observation.
