ABSTRACT
The authors make a review of recent data in the literature and compare them to their own cases between 1983 and 1988. They analyzed eight patients with idiopathic myelofibrosis confirmed with bone marrow biopsy of the posterior iliac wrist with Jamshidi's needle. Most patients were between 55 and 60 years old (5 male and 3 female). Major symptoms were weakness and bleeding (6/8 cases), weight loss and bone distress (4/8 cases). In general, physical signs were splenomegaly and anemia (7/8 cases), hepatomegaly (5/8 cases), and jaundice (2/8 cases). Laboratory features were variable. Most cases were diagnosed in an advanced stage of the disease. Therapy with busulfan, prednisone, oxymetholone and radiotherapy of the spleen was used alone or in combination to relieve compressive abdominal symptoms. This review shows that idiopathic myelofibrosis should be included in the differential diagnosis of patients with hepatosplenomegaly and anemia.
Subject(s)
Primary Myelofibrosis/diagnosis , Adult , Aged , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Primary Myelofibrosis/blood , Primary Myelofibrosis/therapyABSTRACT
A rare case of primary plasma cell leukaemia is presented as a plasmacytic dyscrasia with high number of plasma cells in peripheral blood and bone marrow, few osteolytic lesions and with cardiac and renal failure. The morphology of leukaemic cells were variable ranging from lymphoplasmacytic to differentiated plasma cells. Bence-Jones protein Lambda Chain was found in urine and serum. The patient was treated with chemotherapy (M2 protocol) with survival of 33 months.
Subject(s)
Dysgammaglobulinemia/diagnosis , Immunoglobulin lambda-Chains , Leukemia, Plasma Cell/diagnosis , Adult , Biopsy , Bone Marrow/pathology , Female , Humans , Kidney/physiopathology , Leukemia, Plasma Cell/pathology , Plasma Cells/pathologyABSTRACT
In 45 patients with SLE the frequency of groups B and AB exceeded that of the controls, the difference reaching the double of the standard error. The isoagglutinin titers were quite similar in the two series. There was no association of the disease with the frequency of the secretor type nor with the quantity of group substances or isoagglutinins present in saliva and urine. The isoagglutinin titers in the sera of non-secretors were low.
