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1.
J Pediatr Ophthalmol Strabismus ; 50(4): 204-12, 2013.
Article in English | MEDLINE | ID: mdl-23244243

ABSTRACT

Diffuse unilateral subacute neuroretinitis (DUSN) is a usually unilateral inflammatory disease characterized by an insidious, usually severe loss of peripheral and central vision. Clinical characteristics are manifested in early and late stages. Parasites of different sizes and several species of nematodes have been reported as the etiology of DUSN without conclusive evidence about the specific agent. Because serologic testing has been variable, the definitive diagnosis is made when the clinical characteristics of DUSN are found in conjunction with an intraocular worm. Laser photocoagulation, pars plana vitrectomy, thiabendazole, and albendazole have been used to treat DUSN with variable success.


Subject(s)
Retinitis/complications , Acute Disease , Anthelmintics/therapeutic use , Humans , Laser Coagulation , Retinitis/diagnosis , Retinitis/therapy , Vitrectomy
2.
Am J Ophthalmol ; 153(4): 743-9, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22244523

ABSTRACT

PURPOSE: To describe the determinant clinical signs to diagnose diffuse unilateral subacute neuroretinitis (DUSN) and the main features related to identification of the live worm. DESIGN: Retrospective study performed at the Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil, between 2003 and 2008. METHODS: Patients with early- or late-stage diffuse unilateral subacute neuroretinitis were included. All patients underwent complete ophthalmologic examination and had a minimum of 6 months of follow-up. RESULTS: A total of 121 patients were included. Most patients were younger than 20 years (69.42%). Visual acuity was 20/400 or worse in 86 patients (71.7%). Nine patients (7.43%) presented in the early stage and 112 (92.57%) patients presented in the late stage. Subretinal tracks (91.7%), focal alterations of the retinal pigment epithelium (89.3%), small white spots (80.2%), and optic nerve atrophy (76.9%) were the most frequent clinical features. The subretinal worm was identified in 48 patients (39.66%), and laser treatment to destroy it was performed in all cases. The most common location of the nematode was the posterior pole (21 patients). It was observed that the younger the age, the higher the indices of larvae identification (P=.022). Multifocal yellow-white lesions and vitritis were correlated with identification of the worm (P=.001). Mean logarithm of the minimal angle of resolution visual acuity was 1.466 (20/600) and 1.281 (20/400) before and after laser treatment, respectively (P<.005). CONCLUSIONS: Identification of clinical signs and diagnosis of diffuse unilateral subacute neuroretinitis in its early stage, followed by prompt location and destruction of the worm by photocoagulation, may improve the vision of affected patients.


Subject(s)
Eye Infections, Parasitic/diagnosis , Nematode Infections/diagnosis , Retinitis/diagnosis , Acute Disease , Adolescent , Adult , Child , Child, Preschool , Eye Infections, Parasitic/physiopathology , Eye Infections, Parasitic/surgery , Female , Humans , Laser Coagulation , Male , Nematode Infections/physiopathology , Nematode Infections/surgery , Retina/parasitology , Retina/pathology , Retinitis/physiopathology , Retinitis/surgery , Retrospective Studies , Visual Acuity/physiology , Young Adult
3.
Arq Bras Oftalmol ; 70(3): 413-22, 2007.
Article in Portuguese | MEDLINE | ID: mdl-17768546

ABSTRACT

PURPOSE: Although it has been proposed that retinal vasculature is fractal, no method of standardization has been performed for vascular segmentation or for dimension calculation, thus resulting in great variability among values of fractal dimensions. The present study was designed to determine if estimation of retinal vessel fractal dimensions is dependent on vascular segmentation and dimensional calculation methods. METHODS: Ten eye fundus images were segmented to extract their vascular trees by four computational methods ("multi-threshold", "scale-space", "pixel classification" and "ridge based detection"). Their information, mass-radius and box counting fractal dimensions were calculated and compared with those of the same vascular trees manually segmented (gold standard). RESULTS: The mean vascular tree dimension varied among the groups of different segmentation methods, from 1.39 to 1.47 for box counting, from 1.47 to 1.52 for information and from 1.48 to 1.57 for mass-radius dimensions. The utilization of different vascular segmentation methods and different dimension calculation methods introduced significant difference among fractal dimension of vessels. CONCLUSION: Estimation of retinal vessel fractal dimensions was dependent on both vascular segmentation and dimension calculation methods.


Subject(s)
Fractals , Image Processing, Computer-Assisted , Retinal Vessels/anatomy & histology , Adolescent , Adult , Humans
4.
Ophthalmic Epidemiol ; 11(4): 301-17, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15512992

ABSTRACT

OBJECTIVE: To determine the prevalence of systemic and ocular toxoplasmosis among 1024 students in the city of Natal, Northeastern Brazil, and correlate it with demographic, socioeconomic and epidemiological risk factors. METHODS: The study population was randomly selected, asked to fill out a questionnaire, provide a blood sample for IgG and IgM (MEIA) serology and a hemogram, and undergo an eye examination. RESULTS: The seroprevalence for IgG was 46% (95% CI = 42.9-49.2%) and that for IgM was 1.4% (95% CI = 0.8-2.4%). The prevalence of ocular lesions was 1.15% (95% CI = 0.6-2.0%). In the univariate analyses, confirmed by multivariate analysis, the socioeconomic conditions were determinants in the prevalence of systemic and ocular toxoplasmosis (mother's schooling = literacy/OR = 2.9 and p < 0.001). CONCLUSIONS: The prevalence of systemic toxoplasmosis, although high, was lower than that found in studies performed in the South and Southeast of Brazil, and the incidence of ocular lesions was totally different, being lower by a factor varying from 5 to 17. Although important epidemiological variables, such as owning a cat, drinking unfiltered water or having had contact with lakes or rivers, were found to be correlated with toxoplasmosis in the preliminary analysis, they lost their influence when included in the logistic model. However, further studies must be undertaken to identify the reasons for these findings, including the determination of the strains of Toxoplasma gondii encountered in different regions of the country and the sources of the water utilized by these populations.


Subject(s)
Antibodies, Protozoan/blood , Socioeconomic Factors , Toxoplasmosis, Ocular/epidemiology , Adolescent , Adult , Brazil/epidemiology , Child , Child, Preschool , Confidence Intervals , Female , Fundus Oculi , Humans , Male , Multivariate Analysis , Odds Ratio , Prevalence , Risk Factors , Seroepidemiologic Studies , Toxoplasmosis, Ocular/immunology
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