ABSTRACT
INTRODUCTION: It has been reported that anti-inflammatory drugs used for treatment of pain and discomfort related to orthodontic treatment could slow down tooth movement. However, the effect of these drugs on orthodontic root resorption is not well understood. OBJECTIVES: The aim of this study was to investigate whether the COX-2 inhibitor celecoxib offers some protection against orthodontically induced root resorption. DESIGN: Male Wistar rats were divided into four groups: Groups I and II were treated with saline and celecoxib (10 mg / kg), respectively for 3 days. Groups III and IV were treated with saline and celecoxib for 14 days. The upper left first molars of all rats were moved mesially for 14 days with 50 g of force. An area including the disto-apical aspect of the mesial root of the first molar was processed for histological and histochemical techniques with tartarate-resistant acid phosphatase (TRAP). OUTCOME MEASURE: The degree of root resorption was measured using an image analysis system with a grid-sheet superimposed in the root were resorption lacunae were counted. The number of TRAP-positive cells on the tooth root surface defined as odontoclasts were also evaluated. RESULTS: The results revealed that there were no significant differences in the degree of root resorption and in the number of odontoclasts on the root between the four groups studied. CONCLUSION: The short and long-term celecoxib administration did not suppress the root resorption in case of experimental orthodontic force application.
Subject(s)
Cyclooxygenase 2 Inhibitors/therapeutic use , Pyrazoles/therapeutic use , Root Resorption/drug therapy , Root Resorption/etiology , Sulfonamides/therapeutic use , Tooth Movement Techniques/adverse effects , Animals , Celecoxib , Cyclooxygenase 2 Inhibitors/pharmacology , Dental Stress Analysis , Male , Osteoclasts/drug effects , Pyrazoles/pharmacology , Random Allocation , Rats , Rats, Wistar , Sulfonamides/pharmacologyABSTRACT
This study reports four cases of mucosa ulceration after a 30-minute application of EMLA (0.3 g) as a topical anaesthetic in dentistry. The subjects returned the next day with a white ulceration and desquamation on the application site. EMLA cream should not be applied to the oral mucosa for 30 minutes.
Subject(s)
Anesthesia, Dental/adverse effects , Anesthetics, Local/adverse effects , Lidocaine/adverse effects , Mouth Mucosa/drug effects , Oral Ulcer/chemically induced , Prilocaine/adverse effects , Administration, Topical , Adult , Anesthetics, Local/administration & dosage , Dose-Response Relationship, Drug , Female , Humans , Lidocaine/administration & dosage , Lidocaine, Prilocaine Drug Combination , Prilocaine/administration & dosageABSTRACT
In the last few years allergic reactions to natural rubber latex (NRL) have increased in dental practice affecting both the dental team and patients. Some case reports discuss the potential risks of hypersensitivity to NRL products. An adverse patient reaction after dental rubber dam placement is reported. About 1 min after the isolation of the tooth with a rubber dam the patient presented signs and symptoms of hypersensitivity. Oxygen and intravenous hydrocortisone were administered and the patient kept under observation. After 2 h she had stable vital signs and no more allergics symptoms. It is unclear whether components of the NRL dam or the cornstarch powder incorporated with the rubber dam was responsible for the allergic reaction. Dentists must be aware of the health problem and be prepared for an adequate management in dental practice.
