ABSTRACT
BACKGROUND: An expert consensus meeting had defined the standard lymphadenectomy during pancreatoduodenectomy for an adenocarcinoma of the head of the pancreas. There is a controversy regarding the possibility to perform this optimal lymphadenectomy by minimally invasive approach. PATIENTS: The patient was a 68-year-old man with the diagnosis of an adenocarcinoma of the head of the pancreas. The 3D reconstructions evidenced the existence of a right hepatic artery. TECHNIQUE: The patient was positioned in the French position with the assistant between the legs and the robot at the head. Five trocars were used; the camera was introduced through the umbilicus trocar. The operation began with a peritoneal and liver exploration, and with an inter-aortico-caval picking. Because lymph nodes were noninvaded, pancreatoduodenectomy was decided with the first dissection of the superior mesenteric artery helped with a hanging maneuver. The right hepatic artery was dissected. Each structure of the hepatic pedicle was skeletonized. The camera was switched to the right side. The first jejunal loop was divided with a stapler. The specimen was totally mobilized en bloc, freed from the portal vascular axis with a dissection of the right border of the coeliac trunk. The pancreas was divided. At the end of the dissection, the different arterial and venous structures were skeletonized with a resection of the lymph node group 5-6-8a-12a,b,c-13a,b-14a,b-17a,b. Pathology confirmed R0 resection for a well-differentiated pancreatic adenocarcinoma graded pT3N1 (5/20). CONCLUSIONS: Robotic pancreatoduodenectomy could be performed with an optimal standard lymphadenectomy as recommended by the expert consensus.
Subject(s)
Adenocarcinoma/surgery , Lymph Node Excision/methods , Mesenteric Artery, Superior/surgery , Pancreatic Neoplasms/surgery , Pancreaticoduodenectomy/methods , Robotic Surgical Procedures/methods , Aged , Dissection , Humans , MaleABSTRACT
Over recent years, minimally invasive pancreatic resections have increasingly been reported in the literature. Even though pancreatic surgery is still considered a challenge for surgeons due to its technical difficulties and high morbidity, the development and spread of robotic surgery has highlighted a new interest, which has induced a rapid spread of robotic approaches for pancreatic resections. This study presents a systematic review of the literature regarding robotic pancreaticoduodenectomy and distal pancreatectomy in order to assess the safety and feasibility of robotic pancreatic resection.
Subject(s)
Pancreatectomy/methods , Pancreatic Diseases/surgery , Pancreaticoduodenectomy/methods , Robotic Surgical Procedures/methods , HumansABSTRACT
BACKGROUND: Diverticular disease of the left colon is a common disease, mainly in the population over 50 years of age. The surgical management of acute diverticulitis is remains controversial, especially in severe forms. OBJECTIVE: This study aimed to evaluate the results of laparoscopic surgery for diverticular disease in a tertiary care institution with a specialist interest in minimally invasive surgery. DESIGN: All patients who had elective laparoscopic sigmoidectomy for diverticulitis within eight years at University Hospital of Luxembourg were selected from a retrospective database to evaluate laparoscopic benefit in moderate and severe disease. RESULTS: A total of 155 patients were divided in two groups: Moderate Acute Diverticulitis (MAD) and Severe Acute Diverticulitis (SAD) respectively. The short-term outcomes, after laparoscopic sigmoidectomy, were evaluated. There were not important differences between two groups. CONCLUSIONS: The laparoscopic management of diverticular disease after moderate and severe crisis gives same benefits and short-term outcomes are similar. Elective Laparoscopic surgery is actually the standard of care for moderate and severe diverticular disease in our institution.
Subject(s)
Colon, Sigmoid/pathology , Colon, Sigmoid/surgery , Diverticulitis, Colonic/diagnosis , Diverticulitis, Colonic/surgery , Laparoscopy , Acute Disease , Adult , Aged , Aged, 80 and over , Conversion to Open Surgery , Diverticulitis, Colonic/pathology , Elective Surgical Procedures/methods , Female , Hospitals, University , Humans , Laparoscopy/methods , Length of Stay , Luxembourg , Male , Middle Aged , Patient Readmission , Reoperation , Retrospective Studies , Risk Factors , Severity of Illness Index , Sigmoidoscopy , Treatment OutcomeABSTRACT
BACKGROUND: Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity. OBJECTIVE: We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass. DESIGN: A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes. RESULTS: After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed. CONCLUSIONS: The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.
Subject(s)
Intracellular Signaling Peptides and Proteins/genetics , Membrane Proteins/genetics , Obesity/surgery , Polymorphism, Single Nucleotide , Receptor, Melanocortin, Type 4/genetics , Weight Loss , Diabetes Mellitus/therapy , Female , Follow-Up Studies , Gastric Bypass , Humans , Hypertension/complications , Hypertension/therapy , Laparoscopy , Male , Mutation , Obesity/complicationsABSTRACT
The toxic effect of 84 essential oils was tested at different concentrations on Entamoeba histolytica. 15 of them were the most efficient. 5 of the latter were detailed to give the percentages of their components. Some families of plants have shown an homogeneity in the toxicity of their essential oils, while others, to the contrary, have presented heterogeneous amoebicidal activities. Further investigations should be made to identify amoebicidal effects of essential oils in vivo.
Subject(s)
Amebicides/pharmacology , Oils, Volatile/pharmacology , Animals , Entamoeba histolytica/drug effects , Plants, Medicinal/chemistrySubject(s)
Bicarbonates , Renal Dialysis/methods , Acetates/adverse effects , Acidosis/therapy , Body Weight , Electrocardiography , Female , Humans , Hypotension/chemically induced , Male , Middle Aged , Potassium/poisoning , Renal Dialysis/adverse effects , Uremia/physiopathology , Uremia/therapy , Vascular ResistanceABSTRACT
An intravenous infusion of 3,430mg of PO4- has been given to 11 patients on acetate and to 11 patients on bicarbonate haemodialysis. The 'phosphate spaces' and dialytic removal were determined. The bicarbonate dialysis causes lower values of phosphate pool, total phosphate space, cellular space and phosphate cellular clearance. There is also a greater phosphate removal during bicarbonate dialysis. The better correction of metabolic acidosis and the absence of acetate metabolism are two factors which may be responsible for these phenomena.
Subject(s)
Phosphates/metabolism , Renal Dialysis , Acid-Base Equilibrium , Bicarbonates , Humans , KineticsABSTRACT
27 patients with creatinine clearances ranging from 20 to 2 ml/min were treated daily with 6.9 mg/kg of muzolimine, for 10 to 25 days. The hyperhydration state with oedema decreased gradually in all patients without hypotensive phenomena. Muzolimine benefited hypertension in patients with expansion of the extracellular space and it also strengthened the effect of clonidine or minoxidil. Important diuretic and natriuretic effects were obtained. Metabolic acidosis improved. No subjective adverse reactions to the drug or side effects were noted. High-dose muzolimine appears to be efficacious and safe for short-term treatment in patients with severe chronic renal failure.
Subject(s)
Kidney Failure, Chronic/drug therapy , Muzolimine/therapeutic use , Pyrazoles/therapeutic use , Acid-Base Imbalance/drug therapy , Acidosis/drug therapy , Adult , Aged , Clonidine/therapeutic use , Diuresis/drug effects , Edema/drug therapy , Female , Glomerular Filtration Rate , Humans , Hypertension/drug therapy , Kidney Failure, Chronic/physiopathology , Male , Middle Aged , Muzolimine/adverse effects , Natriuresis/drug effectsABSTRACT
A computerized data bank was created to file the diagnoses from the Surgical Pathology and Cytopathology laboratories in a University Department of Pathology. The diagnoses are divided into separate diagnostic statements, coded according to SNOMed and stored on magnetic tapes. Coding procedures are made easier by the creation of a lexicon of diagnoses used. The use of additional keys, besides SNOMed codes, allows the retention of further information. Several programs perform many data-retrieval operations both routinely and on request in order to meet different goals in the fields of quality control, diagnosis, education and research. The system is characterized by low cost, flexibility and multi-purpose utilization.
