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99mTc-(Me)FGCDEVD, a potential tracer for apoptosis detection.
Bohn, Pierre; Mouchard, Florian; Rouvet, Jean; de Boisgrollier, Anne-Caroline; Vera, Pierre.
Bioorg Med Chem Lett ; 23(5): 1375-8, 2013 Mar 01.
Article in English | MEDLINE | ID: mdl-23337600

ABSTRACT

(Me)FGC(Bz)DEVD was radiolabeled with technetium-99m in high yield. This tracer was preferentially accumulated in apoptotic cells in the in vitro studies. Tumor uptake occurred in vivo after cisplatin injection due to the apoptosis induction, which not observed in the untreated tumors. Therefore, (99m)Tc-(Me)FGCDEVD is a potential tracer for apoptosis detection.


Subject(s)
Apoptosis/physiology , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/pathology , Oligopeptides/chemistry , Radiopharmaceuticals/chemistry , Technetium Compounds/chemistry , Animals , Apoptosis/drug effects , Cell Line, Tumor , Cisplatin/pharmacology , Heterografts , Humans , Isotope Labeling/methods , Lung Neoplasms/drug therapy , Lung Neoplasms/metabolism , Mice , Mice, Nude , Oligopeptides/drug effects , Oligopeptides/pharmacokinetics , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Technetium Compounds/pharmacokinetics
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