ABSTRACT
Neonatal candidemia can occur, however, infections caused by Candida pelliculosa are rare. Here, we describe an outbreak of candidemia caused by C. pelliculosa among babies hospitalized in a neonatal intensive care unit.
Subject(s)
Candida/classification , Candida/isolation & purification , Candidemia/epidemiology , Cross Infection/epidemiology , Disease Outbreaks , Antifungal Agents/pharmacology , Cluster Analysis , DNA, Fungal/genetics , Electrophoresis, Agar Gel , Female , Humans , Infant, Newborn , Intensive Care Units, Neonatal , Male , Microbial Sensitivity Tests , Microsatellite Repeats , Molecular Epidemiology , Molecular Typing , Mycological Typing Techniques , Polymerase Chain ReactionABSTRACT
Non-albicans Candida species are being increasingly reported as causes of nosocomial fungal infections. For example, invasive candidiasis caused by C. tropicalis has been associated with hematologic malignancies. In this study, we report a fatal case of fungemia and a possible urinary and pulmonary infection in a leukemia patient that was due to a strain of C. tropicalis resistant to 2 triazole antifungals.
Subject(s)
Antifungal Agents/therapeutic use , Candida tropicalis/drug effects , Candidiasis/drug therapy , Leukemia, Myeloid, Acute/complications , Triazoles/therapeutic use , Aged , Antifungal Agents/pharmacology , Candida tropicalis/isolation & purification , Candidiasis/complications , Candidiasis/diagnosis , Drug Resistance, Fungal , Fatal Outcome , Humans , Male , Microbial Sensitivity Tests , Shock, Septic/complications , Triazoles/pharmacologyABSTRACT
Fungi are common causes of infection in immunocompromised patients. Candida species are frequently involved in these cases. In order to investigate candidiasis in pediatric patients with cancer, clinical samples were collected from one hundred and twenty two patients interned in the Oswaldo Cruz University Hospital in Recife, Brazil. Yeasts were isolated from thirty-four clinical samples. The species isolated were: Candida albicans (fourteen isolates), C. parapsilosis (nine isolates), C. guilliermondii (two isolates) and C. tropicalis (two isolates). We found that candidemia was most frequent in patients with malignant hematology and that C. parapsilosis infections caused the highest mortality.
