ABSTRACT
A case of angiosarcoma, Raynaud's disease and arteriovenous malformation of the intestinal tract is presented. We propose the association of these three vascular diseases, which has not yet been described. The study of more cases is important in order to understand the physiopathological mechanisms involved.
Subject(s)
Arteriovenous Malformations/etiology , Digestive System/blood supply , Hemangiosarcoma/etiology , Raynaud Disease/etiology , Soft Tissue Neoplasms/etiology , Adult , Arteriovenous Malformations/diagnosis , Arteriovenous Malformations/pathology , Biopsy, Needle , Buttocks , Emergencies , Fatal Outcome , Female , Hemangiosarcoma/diagnosis , Hemangiosarcoma/pathology , Humans , Raynaud Disease/diagnosis , Raynaud Disease/pathology , Soft Tissue Neoplasms/diagnosis , Soft Tissue Neoplasms/pathology , Time FactorsABSTRACT
A man with histologically unequivocal mixed-cellularity Hodgkin's disease, stage IVB, developed an IgG lambda paraproteinemia with bone marrow plasmocytosis but without any other evidence of multiple myeloma. This unusual finding is discussed in the context of recent data suggesting a B-cell origin for some cases of Hodgkin's disease as well as in relation to the evidence of immunoregulatory disturbances in this entity.
Subject(s)
Hodgkin Disease/complications , Immunoglobulin G/analysis , Immunoglobulin lambda-Chains/analysis , Paraproteinemias/complications , B-Lymphocytes/physiology , Hodgkin Disease/immunology , Humans , Lymph Nodes/pathology , Male , Middle AgedABSTRACT
The authors report a patient with Ph1-positive chronic granulocytic leukemia (CGL) who developed "blast crisis" after six years of chronic phase. The presence of mast cell precursors and basophil blasts was demonstrated by ultrastructural morphology and cytochemistry. Membrane phenotype studies with monoclonal antibodies helped in the further characterization of these cells. The possible implication of these findings in the origin of mast cells and the relationship of these cells with basophils are discussed.
