ABSTRACT
INTRODUCTION: Collagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas. OBJECTIVE: To study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment. MATERIAL AND METHODS: This is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected. RESULTS: A total of 18 cases with an incidence of 1.25/10(5) inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflammatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide. CONCLUSION: It is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology.
Subject(s)
Colitis, Collagenous , Retrospective Studies , Adult , Aged , Aged, 80 and over , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Biopsy , Budesonide/administration & dosage , Budesonide/therapeutic use , Colitis, Collagenous/diagnosis , Colitis, Collagenous/drug therapy , Colitis, Collagenous/pathology , Colon/pathology , Colonoscopy , Diarrhea/diagnosis , Diarrhea/etiology , Female , Glucocorticoids/administration & dosage , Glucocorticoids/therapeutic use , Humans , Male , Mesalamine/administration & dosage , Mesalamine/therapeutic use , Middle Aged , Time Factors , Treatment OutcomeSubject(s)
Adjuvants, Immunologic/adverse effects , BCG Vaccine/adverse effects , Mycobacterium bovis , Tuberculosis/etiology , Adjuvants, Immunologic/administration & dosage , Administration, Intravesical , Aged , BCG Vaccine/administration & dosage , Carcinoma, Transitional Cell/drug therapy , Humans , Male , Urinary Bladder Neoplasms/drug therapyABSTRACT
Two cases of tenosynovitis tuberculosa are presented. It was the only tuberculosis manifestation in one of them. The other showed a normal chest X-ray but epithelioid granulomas were found in the bone marrow examination which forced a differential diagnosis to be made of multiple myeloma. The combined therapy, surgery + drug regimen for tuberculosis produced a good evolution.
