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1.
Clin Chim Acta ; 479: 48-55, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29305843

ABSTRACT

BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with chronic lowgrade inflammation. Microparticles (MPs) are extracellular microvesicles released during apoptosis and cellular activation. The MP's pro-coagulant and pro-inflammatory activities are involved in endothelial dysfunction observed in T2DM patients. This study aimed to evaluate the circulating MPs profile in T2DM patients with diabetic kidney disease (DKD) and correlate it with clinical and laboratorial parameters. METHODS: MPs derived from platelets (PMPs), leukocytes (LMPs), endothelial cells (EMPs), and expressing tissue factor (TFMPs) were measured by flow cytometry, in plasma of 39 DKD patients and 30 non-diabetic controls. RESULTS: We observed higher PMPs, LMPs, EMPs, and TFMPs (all p<0.0001) levels in case group as compared to controls. For patients with DKD, circulating MPs levels were influenced by gender, but not by obesity status nor by T2DM onset. Fasting glucose and 25-hydroxyvitamin D levels showed correlation with circulating MPs levels in both groups. CONCLUSIONS: These results suggest that type 2 diabetes mellitus patients with DKD presented higher circulating MPs levels - PMPs, LMPs, EMPs, and TFMPs - which correlated with metabolic alterations.


Subject(s)
Cell-Derived Microparticles/chemistry , Diabetes Mellitus, Type 2/blood , Diabetic Nephropathies/blood , Kidney Diseases/blood , Case-Control Studies , Cross-Sectional Studies , Diabetes Mellitus, Type 2/diagnosis , Diabetic Nephropathies/diagnosis , Female , Humans , Kidney Diseases/diagnosis , Male , Middle Aged
2.
J Mol Neurosci ; 55(1): 217-226, 2015 Jan.
Article in English | MEDLINE | ID: mdl-24770900

ABSTRACT

Chronic thiamine deficiency may be responsible for pathologic changes in the brains of alcoholics, and subclinical episodes of this vitamin deficiency may cause cumulative brain damage. In the present work, the chronic effects of ethanol and its association to a mild thiamine deficiency episode (subclinical model) on neocortical and hippocampal acetylcholinesterase activity were assessed along with their possible association to spatial cognitive dysfunction. The results indicate that in the beginning of the neurodegenerative process, before the appearance of brain lesions, chronic ethanol consumption reverses the effects of mild thiamine deficiency on both spatial cognitive performance and acetylcholinesterase activity without having significant effects on any morphometric parameter.


Subject(s)
Acetylcholinesterase/metabolism , Alcoholism/metabolism , Maze Learning , Spatial Memory , Thiamine Deficiency/metabolism , Alcoholism/complications , Alcoholism/physiopathology , Animals , Hippocampus/metabolism , Hippocampus/physiopathology , Male , Neocortex/metabolism , Neocortex/physiopathology , Rats , Rats, Wistar , Thiamine Deficiency/complications , Thiamine Deficiency/physiopathology
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