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Biomark Med ; 12(5): 447-454, 2018 05.
Article in English | MEDLINE | ID: mdl-29737866

ABSTRACT

AIM: The aim of this study is to evaluate the presence of a particular immunological profile in individuals long-term infected with HTLV-1, followed presenting different clinical courses. MATERIALS & METHODS: Forty-eight individuals were evaluated for 19 cytokines analyzed in cerebrospinal fluid and plasma of patients with HTLV-1 presenting with and without neurological symptoms. RESULTS: Proinflammatory cytokines and the chemokine ligand 11 (ITAC/CXCL11) were increased in individuals with HTLV-1 coursing with neurological symptoms. CONCLUSION: Different cytokines' expression profile in the presence of neurological symptoms may help to understand and characterize the progression for severe clinical presentations.


Subject(s)
Cytokines/blood , Cytokines/cerebrospinal fluid , HTLV-I Infections/complications , Human T-lymphotropic virus 1/physiology , Nervous System Diseases/blood , Nervous System Diseases/cerebrospinal fluid , Biomarkers/blood , Biomarkers/cerebrospinal fluid , Female , Humans , Male , Middle Aged , Nervous System Diseases/complications , Time Factors
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