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1.
Rev Med Liege ; 76(11): 811-816, 2021 Nov.
Article in French | MEDLINE | ID: mdl-34738755

ABSTRACT

Summmary : In Belgium, as in most developed countries, routine antenatal screening for cytomegalovirus (CMV) remains controversial and is not recommended. However, 1-2 % of seronegative pregnant women will develop a primary infection during pregnancy and, with a prevalence of 0.7 % of live births, CMV is the leading cause of congenital infection. Among infected newborns, 20 to 25 % will develop auditory or neurological sequelae. The initial objective of our study was to evaluate, from a cohort of 48 patients followed in the antenatal diagnosis Unit of the University Hospital of Liège, the rates of maternal-fetal transmission, medical termination of pregnancy and rates of sequelae in infected newborns and to compare them with findings found in the literature. The second objective was to synthesize the current state of knowledge on maternal-fetal CMV infection and, in the light of recent data on prenatal treatment with valaciclovir, to propose a screening and management algorithm for primary CMV infection in the first trimester of pregnancy.


En Belgique, ainsi que dans la plupart des pays développés, le dépistage anténatal systématique du cytomégalovirus (CMV) reste controversé et n'est pas recommandé. Toutefois, 1 à 2 % des femmes enceintes séronégatives feront une primo-infection pendant la grossesse et, avec une prévalence de 0,7 % des naissances vivantes, le CMV est la première cause d'infection congénitale. Parmi les nouveau-nés infectés, 20 à 25 % développeront des séquelles auditives ou neurologiques. L'objectif initial de notre étude a été d'évaluer, à partir d'une cohorte de 48 patientes suivies dans l'Unité de diagnostic anténatal du CHU de Liège, les taux de transmission materno-fœtale, d'interruption médicale de grossesse et de séquelles chez les nouveau-nés infectés et de les comparer à ceux retrouvés dans la littérature. Le second objectif a été de synthétiser l'état actuel des connaissances sur l'infection materno-fœtale à CMV et, à la lumière des données récentes sur le traitement anténatal par valaciclovir, de proposer un algorithme de dépistage et de prise en charge de la primo-infection par le CMV au 1er trimestre de la grossesse.


Subject(s)
Cytomegalovirus Infections , Pregnancy Complications, Infectious , Cytomegalovirus , Cytomegalovirus Infections/diagnosis , Cytomegalovirus Infections/epidemiology , Female , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical/prevention & control , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/drug therapy , Prenatal Diagnosis
2.
Rev Med Liege ; 63(12): 737-41, 2008 Dec.
Article in French | MEDLINE | ID: mdl-19180834

ABSTRACT

Pyelectasis is a dilatation of the renal pelvis. It must be differentiated from hydronephrosis which is a dilation of the renal pelvis and of the renal calyces. In this retrospective study, we focused on the treatment and follow up of 31 newborns in whom a pyelectasis had been diagnosed in utero. At the end of the study, 20 babies showed no sign of an urologic disorder whereas 11 babies did. Our study suggests that it is crucial to search for an urologic disorder in the neonatal period when a fetal pyelectasis has been diagnosed.


Subject(s)
Kidney Diseases/diagnostic imaging , Kidney/abnormalities , Ultrasonography, Prenatal , Ureter/abnormalities , Dilatation, Pathologic/diagnostic imaging , Female , Humans , Infant, Newborn , Kidney Diseases/diagnosis , Kidney Diseases/surgery , Kidney Pelvis/diagnostic imaging , Male , Predictive Value of Tests , Pregnancy , Pregnancy Trimester, Second , Pregnancy Trimester, Third , Retrospective Studies , Severity of Illness Index , Treatment Outcome
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