1.
Org Biomol Chem
; 16(1): 48-52, 2017 Dec 19.
Article
in English
| MEDLINE
| ID: mdl-29215120
ABSTRACT
DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.