ABSTRACT
This study compared the antipyretic effectiveness of acetaminophen, ibuprofen, and dipyrone in young children with fever. The results were based on a modified double-blind, randomized, multinational trial that evaluated 628 febrile children, aged 6 months to 6 years. All three drugs lowered temperature in the 555 patients completing the study. Temperature normalization rates in the ibuprofen and dipyrone groups (78% and 82%, respectively) were significantly higher than the acetaminophen group (68%, P = 0.004). After 4 to 6 hours, mean temperature in the dipyrone group was significantly lower than the other groups, demonstrating longer temperature normalization with dipyrone. All three drugs showed comparable tolerability profiles.
Subject(s)
Acetaminophen/therapeutic use , Analgesics, Non-Narcotic/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Body Temperature/drug effects , Dipyrone/therapeutic use , Fever/drug therapy , Ibuprofen/therapeutic use , Acetaminophen/administration & dosage , Acetaminophen/adverse effects , Analgesics, Non-Narcotic/administration & dosage , Analgesics, Non-Narcotic/adverse effects , Analysis of Variance , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Child , Child, Preschool , Dipyrone/administration & dosage , Dipyrone/adverse effects , Double-Blind Method , Female , Humans , Ibuprofen/administration & dosage , Ibuprofen/adverse effects , Infant , Male , Prospective Studies , Sample Size , Time Factors , Treatment OutcomeSubject(s)
Fluid Therapy , Water-Electrolyte Imbalance/therapy , Female , Humans , Infant, Newborn , MaleABSTRACT
The present study was carried out with the purpose of determining whether the use of contraceptives by the mothers constitutes an important factor in the elevation of unconjugated bilirubin in breast fed newborns. One hundred mothers of full term healthy newborns with adequate weights for their gestational ages were asked on this point. Twenty-four hours after birth, breast feeding was initiated and at 72 hours, the level of bilirubins was investigated. The results showed a significant difference in favor of the total bilirubin concentration and its indirect fraction in the 45 infants from mothers who had taken contraceptives.
PIP: 100 mothers, 45 of whom had been on oral contraceptives (OCs), were interviewed with the purpose of determining whether the use of OCs could contribute to elevate the level of unconjugated bilirubin in the blood of breast fed newborns. All infants were full term newborns, with adequate weight for their gestational age. They were breast fed 24 hours after birth, and the level of bilirubin was measured 72 hours after birth. The average level of bilirubin was 13.6 mg/100 ml in infants of mothers who had been on OCs, and 8.6 mg/100 ml for the other group of infants. The literature on the subject presents a great divergence of opinions among the several authors, showing that the mechanism of action of this phenomenon is still partly unknown.
