1.
Org Lett
; 2(2): 163-5, 2000 Jan 27.
Article
in English
| MEDLINE
| ID: mdl-10814272
ABSTRACT
[reaction: see text] A new, very efficient, enantioselective synthesis of the sexual attracting insect pheromone (+)-grandisol has been developed, in which the key step is the double [2 + 2] photocycloaddition of ethylene to a bis(alpha,beta-butenolide) readily available from D-mannitol. The C2 symmetry of the substrate and the appropriate protection of the central diol unit are the crucial features for the high diastereofacial discrimination during the cycloaddition process.
Subject(s)
Terpenes/chemistry , Mannitol/chemistry , Sex Attractants/chemical synthesis , Sex Attractants/chemistry , Stereoisomerism , Terpenes/chemical synthesis
2.
Arch Bronconeumol
; 32(9): 463-74, 1996 Nov.
Article
in Spanish
| MEDLINE
| ID: mdl-9064085
Subject(s)
Antitubercular Agents/therapeutic use , Tuberculosis/drug therapy , Algorithms , Anti-Bacterial Agents , Drug Resistance, Microbial , Drug Therapy, Combination/therapeutic use , Humans , Microbial Sensitivity Tests , Mutation , Mycobacterium tuberculosis/genetics , Treatment Failure , Tuberculosis/complications , Tuberculosis/microbiology
3.
Med Clin (Barc)
; 105(18): 703-7, 1995 Nov 25.
Article
in Spanish
| MEDLINE
| ID: mdl-8538253