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Participation of endogenous corticosteroids in inflammatory response in type 2 streptozotocin diabetic rats.
de Melo, G A N; Sartoretto, J L; Caparroz-Assef, S M; Bersani-Amado, C A; Fortes, Z B; Cuman, R K N.
Pol J Pharmacol ; 56(5): 617-9, 2004.
Article in English | MEDLINE | ID: mdl-15591652

ABSTRACT

The inflammatory response is decreased in diabetic animals. After adrenals removal this impaired response in type 2 diabetic rats evaluated by pleurisy and vascular permeability tests was restored. Our studies demonstrate that endogenous corticosteroids play a partial role in the impaired inflammatory response in type 2 streptozotocin diabetic rats.


Subject(s)
Adrenal Cortex Hormones/physiology , Diabetes Mellitus, Experimental/metabolism , Diabetes Mellitus, Experimental/pathology , Diabetes Mellitus, Type 2/metabolism , Diabetes Mellitus, Type 2/pathology , Inflammation Mediators/physiology , Animals , Male , Rats , Rats, Wistar
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