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High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study.

Kavsak, Peter A; Walsh, Mike; Srinathan, Sadeesh; Thorlacius, Laurel; Buse, Giovanna Lurati; Botto, Fernando; Pettit, Shirley; McQueen, Matthew J; Hill, Stephen A; Thomas, Sabu; Mrkobrada, Marko; Alonso-Coello, Pablo; Berwanger, Otavio; Biccard, Bruce M; Cembrowski, George; Chan, Matthew T V; Chow, Clara K; de Miguel, Angeles; Garcia, Mercedes; Graham, Michelle M; Jacka, Michael J; Kueh, J H; Li, Stephen C H; Lit, Lydia C W; Martínez-Brú, Cecília; Naidoo, Prebashini; Nagele, Peter; Pearse, Rupert M; Rodseth, Reitze N; Sessler, Daniel I; Sigamani, Alben; Szczeklik, Wojciech; Tiboni, Maria; Villar, Juan Carlos; Wang, C Y; Xavier, Denis; Devereaux, P J.

Clin Biochem ; 44(12): 1021-4, 2011 Aug.

Article in English | MEDLINE | ID: mdl-21640092

ABSTRACT

OBJECTIVES: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. DESIGN AND METHODS: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. RESULTS: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT≥14ng/L and 22% (95% CI:17-26%) had an elevation (≥14ng/L) and change (>85%) in hs-TnT. CONCLUSION: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.

Subject(s)

Postoperative Period , Preoperative Period , Troponin T/blood , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Surgical Procedures, Operative

ABSTRACT

Subject(s)

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