[Technical innovations in total extracardiac cavo-pulmonary connection in Fontan-type operation. An experimental study and first 2 operated clinical cases with excellent immediate results]. / Innovaciones técnicas de la conexión cavo-pulmonar total extracardíaca en la cirugía tipo Fontan. Estudio experimental y dos primeros casos clínicos operados con excelentes resultados inmediatos.

INTRODUCTION: Three technical modalities are presented with total extracardiac cava-pulmonary connection, with bidirectional Glenn, as coverage of this type of extracardiac connection for all types of cardiopathies suitable for Fontan type correction. METHODS: Development of an experimental protocol for the perfecting of the three technical variants tested: "Tunnel from inferior cava to right pulmonary artery by means of right atrial wall and vascularized pericardium", "Tunnel from inferior cava to the trunk of the pulmonary artery with or without pulmonary valve with P.T.F.E. hemiconduit" and "Tunnel from inferior cava to the pulmonary graft as a artery with P.T.F.E. graft as a hemiconduit". RESULTS: The first two clinical cases operated on using the third technical variant are presented. Both cases evolved during immediate postoperative period with a very favourable hemodynamic response, with pressures at conduit and P.A. level of 10-12 mmHg, normal cardiac output and sinus rhythm. The later clinical evolution in both cases is very satisfactory. The five cases published by Laschinger with this same technique showed a very favourable evolution during the immediate postoperative period and later. CONCLUSION: The technical facility of its performance, the slight traumatism of this surgery, the important technical advantages with respect to the total cava-pulmonary intraauricular connection and the good initial hemodynamic results make us consider the total extracardiac cava-pulmonary connection as an important contribution in this type of surgery. It is clear that time and greater clinical experience with this type of connection is required for the correct evaluation of all and each one of the numerous theoretical advantages shown and in order to detect possible disadvantages.

[The effects of a benzopyrone derivative in experimental brain edema due to cold in the rabbit]. / Efectos de un derivado benzopirónico en el edema cerebral experimental por frío en el conejo.

On this study, parenchymal changes during a cerebral edema caused by thermic injury (cool) on the rabbit, are analyzed. The work was based on the ultrastructural findings obtained by transmission electronic microscopy and on the effects produced by a benzopironic derived (F-117 Hydrosmina). The injury was produced with solid CO2, previous a craniectomy, on the dura mater of the left hemisphere. Forty rabbits were included into the study, the animals were distributed into five groups (n = 8): a control group and 4 treatment groups. One of the groups received treatment without previous cerebral injury. The group of rabbits with doses of 50 mg/Kg of weight showed focal and diffuse areas of edema alternating with less damaged areas, the edema was evident on the white substance. This group also showed a dissociation of the myelinic fibers and an intracytoplasmatic tumefaction into the glial cells. These findings contrast with the histopathological findings obtained from the rabbits (V), the extracellular edema was poor, the myelinic fiber disorganization was minimal with no vacuolar degeneration and no structural mitochondrial changes had been showed. The discontinuance of the hematoencephalic barrier caused by the cool could be a possible mechanism that causes the opening of the endothelial unions from the capillary vessels, changing their membranes and resulting in a free penetration of the molecule into the cerebral parenchyma.(ABSTRACT TRUNCATED AT 250 WORDS)

[Impotence of arterial origin: experimental models and evaluation of sexual behavior in rats]. / Impuissance d'origine artérielle: modèles expérimentaux et évaluation de la conduite sexuelle chez le rat.

Work on the vascular anatomy and on the physiology of the penis have allowed developing new procedures to treat impotence. This study has dealt with four experimental models of impotence of arterial origin in rats. The assessment was based on sexual behavior tests and on the measurement of the erection capacity index (ECI) measured from the second to the fifth week after interruption of the arterial flow. Four groups of eight rats each were formed. Group A underwent unilateral ligation of the common iliac artery, group B bilateral ligation of the common iliac artery, group C bilateral ligation of the internal iliac arteries and group D ipsilateral ligation of the common iliac and internal iliac arteries. In group A, the percentage of true coituses was 72.7 and 83.3% on the second and third week, respectively. In group B the percentage of false coituses was higher with 82.3%, 90% and 81.2% on the second, third and fourth week, respectively. In group C, the percentage of true coituses ranged from 7.7% to 35.7% during the whole period of observation. The erection capacity index was of 0.24 in group B and 0.23 in group C, with a higher percentage of false coituses in groups C and B. These models can be used to study the physiopathology of impotence of arterial origin.