ABSTRACT
Objetivo: caracterizar o câncer infantojuvenil conforme a Classificação Internacional da Atenção Primária (CIAP-2) em uma unidade de referência em Recife-PE. Método: trata-se de um estudo transversal de abordagem quantitativa, com entrevistas realizadas com os pais/responsáveis pelos pacientes em 2015. A sintomatologia relatada foi classificada conforme a CIAP em sua segunda versão, sendo os dados analisados em medidas absolutas e relativas. Tem aprovação pelo Comitê de Ética em Pesquisa, CAAE 42167315.4.0000.5208. Resultados: predominância do sexo masculino, entre 15-21 anos, com diagnósticos de leucemia, tumores ósseos, linfomas, respectivamente. Conforme a CIAP-2, os sinais/sintomas mais citados foram os inespecíficos. Conclusão: por esta inespecificidade, urge a necessidade de alertar e capacitar os profissionais na suspeição precoce dos sinais e sintomas do câncer infantojuvenil, subsidiando assim um melhor prognóstico.
Objective: to characterize pediatric cancer according to the International Classification of Primary Care (ICPC-2) in a reference center in Recife-PE. Method: this is a cross-sectional study of quantitative approach with interviews with parents/guardians in 2015. The reported symptoms were classified according to the ICPC in its second version, and the data were analyzed in absolute and relative measures. The study has been approved by the Research Ethics Committee, CAAE 42167315.4.0000.5208. Results: The patients were predominantly male, between 15-21 years, and with diagnoses of leukemia, bone tumors and lymphomas, respectively. As According to ICPC-2, the specific signs/symptoms were the most cited. The sites with suspected predominant tumor were the reference units, unless previously mentioned in primary care. Conclusion: due to this nonspecificity, arises the need to alert and empower the professionals on suspicion of early signs and symptoms of cancer children, subsidizing a better prognosis.
Subject(s)
Primary Health Care , NeoplasmsABSTRACT
We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.
Subject(s)
Fungemia/diagnosis , Fungemia/pathology , Hematologic Neoplasms/complications , Saccharomycetales/isolation & purification , Adolescent , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Caspofungin , Echinocandins/therapeutic use , Fungemia/microbiology , Humans , Lipopeptides , Lung/pathology , Male , Microbial Sensitivity Tests , Microbiological Techniques , Microscopy , Radiography, Thoracic , Treatment Outcome , Voriconazole/therapeutic useABSTRACT
Fungal infections are being increasingly reported in patients with malignancies. Pseudozyma aphidis is an opportunistic yeast usually isolated from plants and rarely from human samples. In this study, we report the first case of pulmonary infection due to P. aphidis in a Burkitt lymphoma patient.
Subject(s)
Burkitt Lymphoma/complications , Lung Diseases, Fungal/diagnosis , Lung Diseases, Fungal/pathology , Ustilaginales/isolation & purification , Adolescent , DNA, Fungal/chemistry , DNA, Fungal/genetics , DNA, Ribosomal Spacer/chemistry , DNA, Ribosomal Spacer/genetics , Humans , Lung Diseases, Fungal/microbiology , Male , Molecular Sequence Data , Radiography, Thoracic , Sequence Analysis, DNA , Ustilaginales/classification , Ustilaginales/geneticsABSTRACT
BACKGROUND: Polymorphisms in the genes of folate and methionine metabolism enzymes have been associated with some forms of cancer by affecting DNA synthesis, repair, and methylation. PROCEDURE: A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed to investigate whether the polymorphisms of the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), carrier of reduced folate 1 (RFC-1 A80G) and thymidylate synthase (TYMS 2R > 3R) altered the risk for retinoblastoma. RESULTS: MTR A2756G AG plus GG genotype frequencies were higher in patients than in controls (45% vs. 26%, P = 0.03). Individual carriers of the variant allele G had a 2.02 (95% CI: 1.05-3.92)-fold increased risk for retinoblastoma. In contrast, no association was observed with respect to MTHFR C677T and A1298C, RFC A80G, and TYMS polymorphisms. CONCLUSIONS: This study presents evidence for an association between the MTR A2756G polymorphism and retinoblastoma susceptibility in a Northeast population from Brazil.
Subject(s)
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics , Genetic Predisposition to Disease , Retinal Neoplasms/genetics , Retinoblastoma/genetics , Brazil , Case-Control Studies , Child , Child, Preschool , Genotype , Humans , Infant , Infant, Newborn , Methylenetetrahydrofolate Reductase (NADPH2)/genetics , Polymorphism, Single Nucleotide , Reduced Folate Carrier Protein/genetics , Risk Factors , Thymidylate Synthase/geneticsABSTRACT
Fungi are common causes of infection in immunocompromised patients. Candida species are frequently involved in these cases. In order to investigate candidiasis in pediatric patients with cancer, clinical samples were collected from one hundred and twenty two patients interned in the Oswaldo Cruz University Hospital in Recife, Brazil. Yeasts were isolated from thirty-four clinical samples. The species isolated were: Candida albicans (fourteen isolates), C. parapsilosis (nine isolates), C. guilliermondii (two isolates) and C. tropicalis (two isolates). We found that candidemia was most frequent in patients with malignant hematology and that C. parapsilosis infections caused the highest mortality.