Subject(s)
Calcium Oxalate/analysis , Kidney Transplantation , Kidney/chemistry , Adolescent , Adult , Aged , Child , Crystallization , Female , Humans , Male , Middle AgedABSTRACT
The present review confirms the existence of the so-called "ovarian-derived prorenin-angiotensin cascade". It also describes the physiopathology of the system and, consequently, its role in the genesis of phenomena concerning reproductive function such as ovulation, steroid synthesis and folliculogenesis. Moreover, the "ovarian-derived prorenin-angiotensin cascade" appears to play an important role in the aetiopathogenesis of diseases such as ovarian tumours, ovarian hyperstimulation syndrome and ectopic pregnancy.
Subject(s)
Ovarian Diseases/physiopathology , Ovary/physiopathology , Renin-Angiotensin System/physiology , Animals , Cysteine Endopeptidases/metabolism , Enzyme Activation , Enzyme Precursors/metabolism , Female , Gonadal Steroid Hormones/metabolism , Gonadotropins, Pituitary/physiology , Humans , Menstrual Cycle/physiology , Ovarian Diseases/etiology , Ovarian Hyperstimulation Syndrome/etiology , Ovarian Hyperstimulation Syndrome/physiopathology , Ovarian Neoplasms/etiology , Ovary/blood supply , Ovary/metabolism , Ovulation/physiology , Polycystic Ovary Syndrome/physiopathology , Pre-Eclampsia/physiopathology , Pregnancy , Pregnancy, Ectopic/etiology , Rabbits , Renin/metabolism , Tissue Plasminogen Activator/physiologyABSTRACT
The present review confirms the existence of the so-called "ovarian-derived prorenin-angiotensin cascade". It also describes the physiopathology of the system and, consequently, its role in the genesis of phenomena concerning reproductive function such as ovulation, steroid synthesis and folliculogenesis. Moreover, the "ovarian-derived prorenin-angiotensin cascade" appears to play an important role in the aetiopathogenesis of diseases such as ovarian tumours, ovarian hyperstimulation syndrome and ectopic pregnancy.
Subject(s)
Ovary/physiopathology , Renin-Angiotensin System/physiology , Animals , Female , Humans , Ovarian Follicle/physiology , Ovarian Hyperstimulation Syndrome/physiopathology , Ovarian Neoplasms/physiopathology , Pre-Eclampsia/physiopathology , Pregnancy , Steroids/biosynthesisABSTRACT
In this paper the authors focus attention on the role of gastrin as a carcinogenic factor. The aim was to bring together the numerous controversial studies on this subject, adding the authors' own personal clinical experience. Gastrin (G) is responsible for the development of carcinoids, as has been experimentally shown in Mastomys rats, and more recently in man. This hormone is regarded as a mitogen for cells in the gastroenteric tract; it acts through specific reactors and messengers, including AMPc and protein kinase A (PKA). Its role in the development of other neoplasias of the gastroenteric tract appears to be linked, but not always subordinate, to the presence of growth factors such as: EGF and TGF-alpha, and also to the possible stimulation of oncogens induced by hypergastrinemia.
ABSTRACT
Sixty-six patients have been treated with Panax Ginseng C.A. Meyer extract, of whom 30 oligoastenospermic sine causa (group A), 16 oligoastenospermic with idiopathic varicocele (group B). Twenty age-matched volunteers were used as controls (group C). Use of Panax Ginseng extract showed an increase in spermatozoa number/ml and progressive oscillating motility, an increase in plasma total and free testosterone, DHT, FSH and LH levels, but a decrease in mean PRL. It is suggested that ginsenosides may have an effect at different levels of the hypothalamus-pituitary-testis axis.
Subject(s)
Fertility/drug effects , Panax , Plant Extracts/therapeutic use , Plants, Medicinal , Saponins/therapeutic use , Adult , Humans , Male , Middle AgedABSTRACT
Alzheimer's Disease (AD) is a particular form of degenerative dementia probably due to deposit in the brain cortex of a non soluble protein called beta-A4 amyloid in senile plaque form. beta A4 is an aberrant mutant proteolytic product of Amyloid Protein Precursor (APP) codified on chromosome 21. Trisomy 21 is responsible for Down's Syndrome (DS). Down's patients have been shown to develop a form of Alzheimer's after 50 years of age, and high blood levels of antithyroid antibodies are also present in a significant percentage of these cases. In the present investigation, antithyroid antibody titres have been studied by means of RIA in group of 34 AD patients. As compared to 30 non-demented controls, AD subjects showed a significant increase in the mean values of antithyroglobulin (TgAb) and antimicrosomial (MCSAb) autoantibodies. The physiopathological relationship regarding this association is discussed.
