Harnessing Efficient ROS Generation in Carbon Dots Derived from Methyl Red for Antimicrobial Photodynamic Therapy.

The emergence of drug-resistant pathogenic microorganisms has become a public health concern, with demand for strategies to suppress their proliferation in healthcare facilities. The present study investigates the physicochemical and antimicrobial properties of carbon dots (CD-MR) derived from the methyl red azo dye. The morphological and structural analyses reveal that such carbon dots present a significant fraction of graphitic nitrogen in their structures, providing a wide emission range. Based on their low cytotoxicity against mammalian cells and tunable photoluminescence, these carbon dots are applied to bioimaging in vitro living cells. The possibility of using CD-MR to generate reactive oxygen species (ROS) is also analyzed, and a high singlet oxygen quantum efficiency is verified. Moreover, the antimicrobial activity of CD-MR is analyzed against pathogenic microorganisms Staphylococcus aureus, Candida albicans, and Cryptococcus neoformans. Kirby-Bauer susceptibility tests show that carbon dots synthesized from methyl red possess antimicrobial activity upon photoexcitation at 532 nm. The growth inhibition of C. neoformans from CD-MR photosensitization is investigated. Our results show that N-doped carbon dots synthesized from methyl red efficiently generate ROS and possess a strong antimicrobial activity against healthcare-relevant pathogens.

Effects of fullerene addition on the thermo-optical properties of smectic liquid crystals at the vicinity of the nematic-smectic-A phase transition.

The present work is devoted to the study of the thermo-optical properties of liquid crystals doped with traces of fullerene C(60) at the vicinity of the nematic-smectic-A phase transition. By using the time-resolved Z-scan technique, we measure the temperature dependence of the thermo-optical coefficient and the thermal diffusivity. Our results reveal that the critical behavior of the thermal diffusivity is strongly affected by the fullerene addition. We provide a detailed discussion under the light of the distinct mechanisms behind the thermal transport in liquid-crystal samples.

Elastic mediated force between nanoparticles adsorbed on smectic films under an external field.

Within the harmonic approximation, we analytically determine the elastic-mediated interaction between colloidal nanoparticles adsorbed on the surface of smectic films under the influence of an external field. Both cases of free-standing films and films deposited over a solid substrate are considered. We show that the asymptotic decay (1/R in free-standing and exponential in deposited films) is not altered by the external field. However, the external field plays distinct roles according to the film configuration, the interparticle distance, the film thickness, and the surface tension at the film-gas interface. We provide a detailed discussion under the light of the distinct mechanisms controlling the undulations of the surface layer.

Crossover from tricritical to critical end point behavior in free-standing smectic films.

We study the smectic to nematic (SmA-N) phase transition taking place at the center of a free-standing film that exhibits enhanced surface order due to the anchoring promoted by a surrounding gas. The usual McMillan mean-field approach predicts that the SmA-N transition in bulk samples can be continuous or discontinuous (first or second order) depending on the molecular geometry, with a tricritical point separating these two regimes. Here we show that the additional orientational order imposed by the surface anchoring stabilizes the surface-induced smectic and nematic phases, leading to the breakdown of the tricritical point and to the emergence of a critical end point. We report the full phase diagram, which depicts four distinct structures as the film thickness is reduced.

Field-induced layer thinning transition on free-standing smectic films.

Strongly anchored free-standing smectic films usually present a stepwise reduction of the number of layers when the temperature is raised above the smectic-isotropic bulk transition temperature. Here, we demonstrate that a field-induced layer thinning transition can take place in smectic films with a negative dielectric anisotropy even below the bulk transition temperature. Using an extended McMillan's model, we provide the phase diagram of this layering transition and show that, when the field is raised above the bulk transition field, the film thickness reduction is well described by a power law with an exponent that depends on the temperature and the aspect ratio of the liquid-crystal molecule.