ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways.

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of molecules with oxidizing properties known as ROS. Despite those molecules being implied negatively in aging and numerous diseases, their key role in cellular signaling is evident. ROS control several biological processes such as inflammation, proliferation, and cell death. The redox signaling underlying these cellular events is one characteristic of the new generation of scientists aimed at defining the role of ROS in the cellular environment. The control of redox potential, which includes the balance of the sources of ROS and the antioxidant system, implies an important target for understanding the cells' fate derived from redox signaling. In this review, we summarized the chemical, the redox balance, the signaling, and the implications of ROS in biological aging.

Effects of Baru Almond Oil (Dipteryx alata Vog.) Treatment on Thrombotic Processes, Platelet Aggregation, and Vascular Function in Aorta Arteries.

Background: This study assessed the effects of Baru (Dipteryx alata Vog.) almond oil supplementation on vascular function, platelet aggregation, and thrombus formation in aorta arteries of Wistar rats. Methods: Male Wistar rats were allocated into three groups. The control group (n = 6), a Baru group receiving Baru almond oil at 7.2 mL/kg/day (BG 7.2 mL/kg, n = 6), and (iii) a Baru group receiving Baru almond oil at 14.4 mL/kg/day (BG 14.4 mL/kg, n = 6). Baru oil was administered for ten days. Platelet aggregation, thrombus formation, vascular function, and reactive oxygen species production were evaluated at the end of treatment. Results: Baru oil supplementation reduced platelet aggregation (p < 0.05) and the production of the superoxide anion radical in platelets (p < 0.05). Additionally, Baru oil supplementation exerted an antithrombotic effect (p < 0.05) and improved the vascular function of aorta arteries (p < 0.05). Conclusion: The findings showed that Baru oil reduced platelet aggregation, reactive oxygen species production, and improved vascular function, suggesting it to be a functional oil with great potential to act as a novel product for preventing and treating cardiovascular disease.

Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats.

Carboxymethyl-glucan is a semi-synthetic derivative of ß-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sought to expand understanding of the effects of carboxymethyl-glucan on vascular and platelet functions in a hypertensive animal model. Spontaneously hypertensive rats and their normotensive Wistar-Kyoto controls were assigned to five groups: control, carboxymethyl-glucan (60 mg kg-1), control spontaneously hypertensive rats, spontaneously hypertensive rats carboxymethyl-glucan (20 mg kg-1), and spontaneously hypertensive rats carboxymethyl-glucan (60 mg kg-1). Animals were treated for four weeks with carboxymethyl-glucan at doses of 20 and 60 mg kg-1 orally, and control rats received saline as a placebo. Vascular reactivity, platelet aggregation, and reactive oxygen species production were evaluated at the end of treatment. The results showed that carboxymethyl-glucan improved vascular function and reduced platelet aggregation, mainly at a 60 mg kg-1 dose. However, despite these effects, there was no reduction in levels of reactive oxygen species. These findings suggested that carboxymethyl-glucan modulates endothelial function. It also acts as a platelet antiaggregant, which is an interesting resource for managing hypertension and its thrombotic complications.

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases.

The global population above 60 years has been growing exponentially in the last decades, which is accompanied by an increase in the prevalence of age-related chronic diseases, highlighting cardiovascular diseases (CVDs), such as hypertension, atherosclerosis, and heart failure. Aging is the main risk factor for these diseases. Such susceptibility to disease is explained, at least in part, by the increase of oxidative stress, in which it damages cellular components such as proteins, DNA, and lipids. In addition, the chronic inflammatory process in aging "inflammaging" also contributes to cell damage, creating a stressful environment which drives to the development of CVDs. Taken together, it is possible to identify the molecular connection between oxidative stress and the inflammatory process, especially by the crosstalk between the transcription factors Nrf-2 and NF-κB which are mediated by redox signalling and are involved in aging. Therapies that control this process are key targets in the prevention/combat of age-related CVDs. In this review, we show the basics of inflammation and oxidative stress, including the crosstalk between them, and the implications on age-related CVDs.